Document Detail

Renal and prostatic malakoplakia associated with submassive hepatic necrosis. A case report with immunocytochemical, ultrastructural and X-ray analytical observations.
MedLine Citation:
PMID:  3776537     Owner:  NLM     Status:  MEDLINE    
An autopsy case of malakoplakia involving the kidney and prostate was reported. The case was a 58-year-old Japanese male with submassive hepatic necrosis of three and half months' duration. He received 20 to 40 mg of prednisolone daily during the course of the disease (total 2,700 mg). Malakoplakic lesions were incidentally found in the right renal parenchyma and prostate at autopsy. The lesions were characterized microscopically by an accumulation of macrophages with PAS-positive intracytoplasmic granules and with intracytoplasmic inclusions of owl's eye appearance called Michaelis-Gutmann bodies and, electronmicroscopically, by numerous phagolysosomes with varying numbers of bacteria. Immunocytochemical stain revealed that the bodies were positive for lysozyme, indicating that the Michaelis-Gutmann bodies are of lysosomal origin. No calcium, phosphorous, and iron were demonstrated in them by X-ray microanalysis, suggesting that they are of immature form in which a mineralization does not take place as yet. Malakoplakia has not been previously described in association with submassive hepatic necrosis. Administration of a large amount of steroid for the treatment of submassive hepatic necrosis was suspected to be implicated in the development of the malakoplakia in the present case.
A Nonomura; N Kono; E Takazakura; G Ohta
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  36     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-12-11     Completed Date:  1986-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1251-62     Citation Subset:  IM    
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MeSH Terms
Electron Probe Microanalysis
Kidney Diseases / pathology*
Liver / pathology*,  ultrastructure
Malacoplakia / pathology*
Microscopy, Electron
Middle Aged
Prostatic Diseases / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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