Document Detail

Renal proliferative and phenotypic changes in rats with two-kidney, one-clip Goldblatt hypertension.
MedLine Citation:
PMID:  8179853     Owner:  NLM     Status:  MEDLINE    
Angiotensin II (AII) is a vasoconstrictive peptide with hypertrophic and mitogenic effects on many cell types. Previous studies have shown that in vivo administration of AII in rats results in proliferation of, and phenotypic changes in, many renal cell populations, but in doses also causing hypertension. Thus, it was not possible to differentiate nonhemodynamic from hypertensive effects of AII. Therefore, we studied rats with renin-dependent, AII-mediated hypertension (the two-kidney, one-clip Goldblatt model; mean systolic blood pressure 238 +/- 48 v 140 +/- 6 mm Hg in sham-operated controls). The unclipped kidneys, which were exposed to high blood pressure, developed significant glomerular and tubulointerstitial injury, tubulointerstitial cell proliferation, dense focal interstitial monocyte-macrophage influx, increased deposition of types I and IV collagen, as well as increased cellular expression of desmin and actin, in tubulointerstitial areas when examined at 11 weeks. In contrast, clipped kidneys, protected from hypertension but with high local renin expression, had minimal abnormalities. These studies suggest that in this model increased renin, and presumably AII, does not mediate significant proliferative or phenotypic changes in the kidney in the absence of hypertension at 11 weeks.
E Eng; M Veniant; J Floege; J Fingerle; C E Alpers; J Menard; J P Clozel; R J Johnson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  7     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-16     Completed Date:  1994-06-16     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  177-85     Citation Subset:  IM    
Department of Medicine, University of Washington, Seattle 98195.
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MeSH Terms
Angiotensin II / physiology
Cell Division / physiology
Cytoskeletal Proteins / metabolism
Fibrosis / pathology
Hypertension, Renovascular / metabolism,  pathology*
Kidney / metabolism,  pathology*
Leukocytes / metabolism
Macrophages / physiology
Rats, Wistar
Renin / metabolism,  physiology
Grant Support
Reg. No./Substance:
0/Cytoskeletal Proteins; 11128-99-7/Angiotensin II; EC

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