Document Detail

Renal progenitors: an evolutionary conserved strategy for kidney regeneration.
MedLine Citation:
PMID:  23338209     Owner:  NLM     Status:  MEDLINE    
Following kidney injury, repair can result in functional tissue becoming a patch of cells and disorganized extracellular matrix--a scar--or it can recapitulate the original tissue architecture through the process of regeneration. Regeneration can potentially occur in all animal species and humans. Indeed, the repair of portions of the existing nephron after tubular damage, a response that has been designated classically as cellular regeneration, is conserved in all animal species from the ancestral phases of evolution. By contrast, another type of regenerative response--nephron neogenesis--has been described in lower branches of the animal kingdom, but does not occur in adult mammals. Converging evidence suggests that a renal progenitor system is present in the adult kidney across different stages of evolution, with renal progenitors having been identified as the main drivers of kidney regenerative responses in fish, insects, rodents and humans. In this Review, we describe similarities and differences between the renal progenitor systems through evolution, and propose explanations for how progressive kidney adaptation to environmental changes both required and permitted neonephrogenesis to be given up and for cellular regeneration to be retained as the main regenerative strategy. Understanding the mechanisms that drive renal progenitor growth and differentiation represent the key step for modulating this potential for therapeutic purposes.
Paola Romagnani; Laura Lasagni; Giuseppe Remuzzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-22
Journal Detail:
Title:  Nature reviews. Nephrology     Volume:  9     ISSN:  1759-507X     ISO Abbreviation:  Nat Rev Nephrol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-21     Revised Date:  2014-10-07    
Medline Journal Info:
Nlm Unique ID:  101500081     Medline TA:  Nat Rev Nephrol     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-46     Citation Subset:  IM    
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MeSH Terms
Acute Kidney Injury / physiopathology*
Biological Evolution
Drosophila / physiology
Kidney / embryology*,  physiology*
Nephrons / physiology
Organogenesis / physiology
Regeneration / physiology*
Stem Cells / cytology,  physiology
Comment In:
Nat Rev Nephrol. 2014 Sep;10(9):491   [PMID:  25116193 ]
Nat Rev Nephrol. 2014 Sep;10(9):491   [PMID:  25116194 ]

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