| Renal phospholipase C and diglyceride lipase activity in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 3474208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phospholipase C activity and diglyceride lipase activity were studied in the renal cortex and medulla of 10- and 40-week-old stroke-prone spontaneously hypertensive rats (SHRSP) and age-matched normotensive Wistar-Kyoto rats (WKY). Enhanced phospholipase C activity was found in the cortical and medullary cytosol of kidney from SHRSP, and microsomal diglyceride lipase in SHRSP also increased. In SHRSP, phospholipase C and diglyceride lipase activities increased with age, but this increase was not evident in WKY. Phospholipase C had high substrate specificity for phosphatidylinositol in renal cytosol of both WKY and SHRSP. The increased activities were accompanied by prostaglandin E2 synthesis in renal medullary microsomes of 10-week-old SHRSP and were also present in the kidney of 40-week-old SHRSP. Total phospholipid and arachidonic acid contents in kidney were markedly high in the medulla of 10-week-old SHRSP, but these lipids were decreased in 40-week-old SHRSP. These results suggest that phospholipids and arachidonic acid in SHRSP may be genetically high and that the activated phospholipase C and diglyceride lipase hydrolyze phospholipids, providing arachidonic acid for prostaglandin synthesis, which results in a decrease of phospholipids and arachidonic acid in the kidney of 40-week-old SHRSP. These studies demonstrate that a phosphatidylinositol-specific phospholipase C-prostaglandin synthetic system may play an important role in the course of hypertension in SHRSP. |
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Authors:
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H Kawaguchi; H Okamoto; H Saito; H Yasuda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension Volume: 10 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-08-12 Completed Date: 1987-08-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 100-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dinoprostone Hypertension / enzymology*, metabolism Kidney / enzymology*, metabolism Kidney Cortex / enzymology, metabolism Kidney Medulla / enzymology, metabolism Lipoprotein Lipase / metabolism* Male Prostaglandins E / biosynthesis Rats Rats, Inbred SHR Rats, Inbred WKY Type C Phospholipases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 363-24-6/Dinoprostone; EC 3.1.1.34/Lipoprotein Lipase; EC 3.1.4.-/Type C Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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