Document Detail

Renal phospholipase C and diglyceride lipase activity in spontaneously hypertensive rats.
MedLine Citation:
PMID:  3474208     Owner:  NLM     Status:  MEDLINE    
Phospholipase C activity and diglyceride lipase activity were studied in the renal cortex and medulla of 10- and 40-week-old stroke-prone spontaneously hypertensive rats (SHRSP) and age-matched normotensive Wistar-Kyoto rats (WKY). Enhanced phospholipase C activity was found in the cortical and medullary cytosol of kidney from SHRSP, and microsomal diglyceride lipase in SHRSP also increased. In SHRSP, phospholipase C and diglyceride lipase activities increased with age, but this increase was not evident in WKY. Phospholipase C had high substrate specificity for phosphatidylinositol in renal cytosol of both WKY and SHRSP. The increased activities were accompanied by prostaglandin E2 synthesis in renal medullary microsomes of 10-week-old SHRSP and were also present in the kidney of 40-week-old SHRSP. Total phospholipid and arachidonic acid contents in kidney were markedly high in the medulla of 10-week-old SHRSP, but these lipids were decreased in 40-week-old SHRSP. These results suggest that phospholipids and arachidonic acid in SHRSP may be genetically high and that the activated phospholipase C and diglyceride lipase hydrolyze phospholipids, providing arachidonic acid for prostaglandin synthesis, which results in a decrease of phospholipids and arachidonic acid in the kidney of 40-week-old SHRSP. These studies demonstrate that a phosphatidylinositol-specific phospholipase C-prostaglandin synthetic system may play an important role in the course of hypertension in SHRSP.
H Kawaguchi; H Okamoto; H Saito; H Yasuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  10     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-08-12     Completed Date:  1987-08-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  100-6     Citation Subset:  IM    
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MeSH Terms
Hypertension / enzymology*,  metabolism
Kidney / enzymology*,  metabolism
Kidney Cortex / enzymology,  metabolism
Kidney Medulla / enzymology,  metabolism
Lipoprotein Lipase / metabolism*
Prostaglandins E / biosynthesis
Rats, Inbred SHR
Rats, Inbred WKY
Type C Phospholipases / metabolism*
Reg. No./Substance:
0/Prostaglandins E; 363-24-6/Dinoprostone; EC Lipase; EC 3.1.4.-/Type C Phospholipases

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