Document Detail

Renal pericytes: regulators of medullary blood flow.
MedLine Citation:
PMID:  23126245     Owner:  NLM     Status:  MEDLINE    
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli. DVR are composed of a continuous endothelium, intercalated with smooth muscle-like cells called pericytes. Pericytes have been shown to alter the diameter of isolated and in situ DVR in response to vasoactive stimuli that are transmitted via a network of autocrine and paracrine signalling pathways. Vasoactive stimuli can be released by neighbouring tubular epithelial, endothelial, red blood cells and neuronal cells in response to changes in NaCl transport and oxygen tension. The experimentally described sensitivity of pericytes to these stimuli strongly suggests their leading role in the phenomenon of MBF autoregulation. Because the debate on autoregulation of MBF fervently continues, we discuss the evidence favouring a physiological role for pericytes in the regulation of MBF and describe their potential role in tubulo-vascular cross-talk in this region of the kidney. Our review also considers current methods used to explore pericyte activity and function in the renal medulla.
T M Kennedy-Lydon; C Crawford; S S P Wildman; C M Peppiatt-Wildman
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-06
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  207     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-09     Completed Date:  2013-07-22     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  212-25     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
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MeSH Terms
Kidney Medulla / blood supply*,  cytology
Pericytes / physiology*
Renal Circulation / physiology*
Grant Support
G0700206//Medical Research Council

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