Document Detail


Renal perfusion pressure and renin secretion in bilaterally renal denervated sheep.
MedLine Citation:
PMID:  7828086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To further investigate the influence of renal nerves on renin secretion, the renin secretion responses to step reductions of renal perfusion pressure (RPP) were studied in conscious sheep with innervated kidneys (n = 5) and with bilaterally denervated kidneys (n = 5). The average basal level of RPP in sheep with denervated kidneys (82 +/- 4 mmHg; 1 mmHg = 133.3 Pa) was similar to that in sheep with innervated kidneys (83 +/- 3 mmHg). RPP was reduced in four sequential 15-min steps, to a final level of 54 +/- 2 mmHg in sheep with innervated kidneys and to 57 +/- 1 mmHg in denervated sheep. The renin secretion rate was increased as RPP was reduced in sheep with innervated kidneys. Baseline peripheral plasma renin activity was reduced and there was almost no response of renin secretion rate to reduction of RPP in sheep with denervated kidneys. Also, baseline renal blood flow, urine flow rate, sodium excretion rate, and potassium excretion rate were higher in sheep with denervated kidneys than those with innervated kidneys. Baseline plasma angiotensin II was similar in both groups of sheep. As RPP was decreased, plasma angiotensin II was increased in sheep with innervated kidneys, but was not RPP or renal denervation. In conclusion, hormonal factors, such as angiotensin II and atrial natriuretic factor, do not account for the dramatic suppression of renin secretion in response to the reduction of RPP in sheep with bilateral renal denervation. Renal nerves are a necessary component in the control of renin secretion during reduction of RPP and may contribute to the regulation of baseline plasma renin activity and sodium excretion rate in conscious ewes.
Authors:
L Fan; S Mukaddam-Daher; J Gutkowska; B S Nuwayhid; E W Quillen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  72     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  782-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, McGill University, Montréal, QC, Canada.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / blood
Animals
Atrial Natriuretic Factor / blood
Blood Pressure / physiology*
Denervation
Female
Kidney / innervation,  physiology*
Perfusion
Pressoreceptors / physiology
Renal Circulation / physiology*
Renin / blood*
Sheep
Urodynamics / physiology
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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