Document Detail

Renal osteopenia - an assessment of long-term therapy with vitamin D analogues.
MedLine Citation:
PMID:  232916     Owner:  NLM     Status:  MEDLINE    
Renal bone disease was assessed for an average of 5.5 years in 9 patients on maintenance haemodialysis. The investigative methods included serial biochemical estimations, radiographic skeletal surveys and quantitative bone histology. Repeated bone mineral analyses and neutron activation analyses of a hand were also performed in order to monitor changes in skeletal calcium content. Before treatment, progressive osteodystrophy was demonstrated by all techniques. Following therapy with the vitamin D analogues, all patients noted symptomatic improvement; serum alkaline phosphatase reverted to normal and serum parathyroid hormone concentrations decreased. Radiographically, subperiosteal erosions healed while the histological features of osteomalacia and osteitis fibrosa were abolished. Both bone mineral and neutron activation analyses indicated that progressive skeletal demineralisation had been halted. However, a sustained increase in the overall mineral content of bone was not demonstrated. Thus, vitamin D therapy although improving the biochemical, radiological, and histological features of renal osteodystrophy may not restore bone mass to osteopenic bone.
G R Catto; B J Junor; R A Fraser; F W Smith; K V Ettinger; N Edward; M MacLeod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  16     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1979  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  637-43     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / blood
Bone Diseases / drug therapy*
Bone and Bones / pathology
Cholecalciferol / therapeutic use
Long-Term Care
Osteomalacia / pathology
Parathyroid Hormone / blood
Periosteum / radiography
Vitamin D / analogs & derivatives*
Reg. No./Substance:
0/Minerals; 0/Parathyroid Hormone; 1406-16-2/Vitamin D; 67-97-0/Cholecalciferol; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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