Document Detail

Renal organogenesis: what can it tell us about renal repair and regeneration?
MedLine Citation:
PMID:  22198432     Owner:  NLM     Status:  MEDLINE    
The increasing prevalence of chronic kidney disease in the absence of new treatment modalities has become a strong driver for innovation in nephrology. An increasing understanding of stem cell biology has kindled the prospects of regenerative options for kidney disease. However, the kidney itself is not a regenerative organ, as all the nephrons are formed during embryonic development. Here, we will investigate advances in the molecular genetics of renal organogenesis, including what this can tell us about lineage relationships, and discuss how this may serve to inform us about both the normal processes of renal repair and options for regenerative therapies.
Melissa H Little
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Organogenesis     Volume:  7     ISSN:  1555-8592     ISO Abbreviation:  Organogenesis     Publication Date:    2011 Oct-Dec
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-08-08     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101253266     Medline TA:  Organogenesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-41     Citation Subset:  IM    
Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia.
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MeSH Terms
Aging / genetics
Kidney / embryology*,  metabolism,  pathology,  physiology*
Mesenchymal Stromal Cells / cytology,  metabolism
Organogenesis* / genetics
Regeneration / genetics,  physiology*
Wound Healing* / genetics
Grant Support

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