Document Detail

Renal noradrenergic and dopaminergic activity in patients with borderline essential hypertension.
MedLine Citation:
PMID:  2427868     Owner:  NLM     Status:  MEDLINE    
An opposite modulatory influence of renal noradrenergic and dopaminergic activities on sodium excretion has been suggested. In this study urinary noradrenaline (UNA) and dopamine (UDA) excretion were evaluated in patients with borderline essential hypertension (BH; n = 9) and in patients with established essential hypertension (EH; n = 11) as well as in normal subjects (NT, n = 8), during normal sodium and potassium intake. Measurements were performed on fractionated urine collections on two separate days: on the first day under basal conditions and on the second day after saline infusion (SAL), 2L/2h, i.v. In BH, basal UNA and UDA were higher with respect to NT and EH. The difference was significant (p less than 0.05) in urine collected between 8 and 14 h. In all three groups, SAL induced a significant decrease in UNA and a significant increase in UDA; the decrease in UNA after SAL was significantly lower in EH in respect to BH and NT. In conclusion, the increased UDA in BH may represent a compensatory mechanism to a defect in sodium excretion, possibly due to elevated renal and/or systemic noradrenergic activity; the normal response to volume and salt loading suggests that the physiological modulation of sympathetic tone is still preserved in BH.
M Castellano; M Beschi; E Agabiti-Rossi; M L Muiesan; G Romanelli; F Falo; M Malerba; G Muiesan
Related Documents :
18067098 - The association of the sodium "setpoint" to interdialytic weight gain and blood pressur...
6399318 - Interaction between the natriuretic effects of renal perfusion pressure and the antinat...
11710758 - Dominant effect of supplemented-sucrose on the low protein diet-induced increase in blo...
23446508 - Optimizing the closed suction surgical drainage system.
2121388 - Cardiac allograft function with corticosteroid-free maintenance immunosuppression.
12771768 - Blood gas changes in the corpora cavernosa: metabolic and histomorphometric implication...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  8 Suppl 5     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-10-15     Completed Date:  1986-10-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S116-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Dopamine / urine*
Hypertension / metabolism,  urine*
Kidney / metabolism*
Middle Aged
Norepinephrine / urine*
Sodium / diagnostic use
Reg. No./Substance:
51-41-2/Norepinephrine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Blood pressure levels in adolescents: the Milan Study.
Next Document:  Adrenaline responsiveness in borderline hypertension.