Document Detail

Renal nerve activity does not contribute to the development of renovascular hypertension in rats with abdominal aortic constriction.
MedLine Citation:
PMID:  2053447     Owner:  NLM     Status:  MEDLINE    
This study examines the influence of renal nerves on the development of renovascular hypertension in proximal aortic constricted rats. The rats were studied 1 week after unilateral or bilateral denervation of the renal artery. Denervation had no effect on the increase in mean arterial pressure induced by the constriction. The glomerular filtration rate and filtration fraction in control and in proximal aortic constricted rats were not influenced by the denervation. The Na excretion was increased in the denervated kidney both in control and in proximal aortic constricted rats. Plasma angiotensin II levels were not different from controls in innervated or unilaterally denervated proximal aortic constricted rats. In bilaterally denervated proximal aortic constricted rats the plasma angiotensin II levels were significantly higher. The renovascular hypertension and the alteration in renal function in proximal aortic constricted rats are not dependent on renal nerve activity.
A C Eklöf; T Hökflet; A Aperia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  141     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-07-19     Completed Date:  1991-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  71-7     Citation Subset:  IM    
Department of Pediatrics, St Görans Children's Hospital, Stockholm, Sweden.
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MeSH Terms
Angiotensin II / blood
Aorta, Abdominal / physiopathology*
Blood Pressure
Calcitonin Gene-Related Peptide / metabolism
Constriction, Pathologic
Hypertension, Renovascular / etiology*,  physiopathology
Kidney / innervation*,  physiopathology
Neurons, Afferent / pathology
Neuropeptide Y / metabolism
Rats, Inbred Strains
Sodium / urine
Reg. No./Substance:
0/Neuropeptide Y; 11128-99-7/Angiotensin II; 7440-23-5/Sodium; 83652-28-2/Calcitonin Gene-Related Peptide

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