Document Detail

Renal morphology in pigs with experimental hyperparathyroidism. Ultrastructural findings.
MedLine Citation:
PMID:  1124648     Owner:  NLM     Status:  MEDLINE    
Ultrastructural examinations were performed in three groups of pigs; one sham-operated control group, one group subjected to thyroidectomy, and another group injected with parathormone after thyroidectomy (TX + PTH). Attention was mainly paid to the localization and structural details of the calcium deposits which were found in the TX + PTH group 78 and 150 hours after the first PTH injection. Calcium deposits were found in the epithelial cells and lumina of the tubular system, especially in the proximal convoluted tubules. It is suggested that calcium first is deposited in mitochondria and cytoplasmic vacuoles and that larger calcific bodies, occasionally with concentric lamellation, are formed by coalescence of small calcific particles, and that the calcium deposits induce degenerative changes in the tubular epithelium which may lead to discharge of calcific material into the lumina.
L Boquist; B Fåhraeus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pathologica et microbiologica Scandinavica. Section A, Pathology     Volume:  83     ISSN:  0365-4184     ISO Abbreviation:  Acta Pathol Microbiol Scand A     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-07-07     Completed Date:  1975-07-07     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  7508468     Medline TA:  Acta Pathol Microbiol Scand A     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  139-49     Citation Subset:  IM    
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MeSH Terms
Calcinosis / pathology
Hyperparathyroidism / chemically induced,  pathology*
Kidney / ultrastructure*
Kidney Tubules / drug effects,  ultrastructure
Parathyroid Hormone / pharmacology
Time Factors
Reg. No./Substance:
0/Parathyroid Hormone

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