Document Detail

Renal metabolism and ammoniagenesis during acute respiratory alkalosis in the dog.
MedLine Citation:
PMID:  6498624     Owner:  NLM     Status:  MEDLINE    
Acute respiratory alkalosis (blood pH, 7.60; arterial PCO2, 15 mmHg (1 mmHg = 133.322 Pa); plasma bicarbonate, 14 mM) was induced in nine anesthetized dogs by increasing their respiratory rate and depth. Renal glutamine extraction and ammonia production expressed per 100 mL of glomerular filtration rate did not change during acute hypocapnia, whereas arterial glutamine concentration decreased significantly from 0.47 to 0.36 mM. Hypocapnia did not change plasma potassium concentration and its urinary excretion. Acute hypocapnia increased lactate extraction and pyruvate production, whereas citrate extraction and glutamate and alanine production did not change. Citraturia remained minimal. Renal cortical glutamine concentration fell from 0.64 to 0.38 mM during hypocapnia while alpha-ketoglutarate, glutamate, malate, oxaloacetate, and citrate did not change. Lactate concentration rose from 1.1 to 2.0 mM. Glutamine concentration in the liver and muscle decreased following acute hypocapnia. Our data are compatible with the hypothesis that an acute respiratory alkalosis might not result in any change in the hydrogen ion concentration and (or) gradient between the mitochondrial matrix and the cytosol. Consequently, renal glutamine extraction and ammonia production are not reduced, renal cortical concentrations of relevant metabolites in the ammoniagenic pathway are not changed, and renal handling of citrate remains unaffected.
A Gougoux; P Vinay; M Cardoso; M Duplain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  62     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1985-01-14     Completed Date:  1985-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1129-35     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Alkalosis, Respiratory / metabolism*
Ammonia / metabolism*
Glomerular Filtration Rate
Glutamine / metabolism
Hydrogen-Ion Concentration
Ketoglutaric Acids / metabolism
Kidney / metabolism*
Kidney Cortex / metabolism
Liver / metabolism
Muscles / metabolism
Reg. No./Substance:
0/Ketoglutaric Acids; 328-50-7/alpha-ketoglutaric acid; 56-85-9/Glutamine; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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