Document Detail

Renal mechanisms for suppression of renin secretion by atrial natriuretic factor.
MedLine Citation:
PMID:  2941371     Owner:  NLM     Status:  MEDLINE    
The effects of synthetic atrial natriuretic factor on renin secretion were examined in anesthetized dogs with either a single filtering kidney or a single denervated nonfiltering kidney. In dogs with a single filtering kidney (Series 1, n = 6), a priming dose of atrial natriuretic factor (2 micrograms/kg, i.v.) followed by sustained intravenous infusions at doses of 200 and 400 ng/kg/min for 20 minutes each produced striking decrements (p less than 0.05) in renin secretion, from 1083 +/- 322 to 205 +/- 120 and 286 +/- 168 ng of angiotensin I per minute. This fall in renin secretion was associated with significant increases (p less than 0.05) in creatinine clearance, urine flow, sodium excretion, and the filtered load of sodium. Renal blood flow increased only transiently. In dogs with a single denervated nonfiltering kidney (Series 2, n = 6), infusion of atrial natriuretic factor at these doses also produced marked inhibition (p less than 0.05) of renin secretion, from 311 +/- 98 to 72 +/- 22 and 91 +/- 37 ng of angiotensin I per minute. Renal blood flow remained significantly elevated (p less than 0.05) throughout the infusion, in contrast to renal blood flow in Series I. Similar results were obtained in a third series of dogs (n = 6) with a single denervated nonfiltering kidney, during sustained intrarenal arterial infusions of atrial natriuretic factor. These results suggest that an increase in the sodium load delivered to the macula suppression of renin secretion by atrial natriuretic factor is mediated through its interactions with the two intrarenal receptor mechanisms, the renal vascular receptor and the macula densa.(ABSTRACT TRUNCATED AT 250 WORDS)
D Villarreal; R H Freeman; J O Davis; K M Verburg; R C Vari
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  8     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-25     Completed Date:  1986-07-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  II28-35     Citation Subset:  IM    
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MeSH Terms
Atrial Natriuretic Factor / pharmacology*
Blood Pressure / drug effects
Creatinine / metabolism
Glomerular Filtration Rate / drug effects
Kidney / drug effects*,  innervation,  physiology
Metabolic Clearance Rate
Potassium / blood
Renal Circulation / drug effects
Renin / secretion*
Sodium / blood
Reg. No./Substance:
60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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