| Renal involvement in patients with hepatitis C virus infection. | |
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MedLine Citation:
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PMID: 20404422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Hepatitis C virus (HCV) infection is a hepatotropic virus causing a variety of extrahepatic immunological manifestations and is a risk factor of a variety of extrahepatic diseases, such as mixed cryoglobulinemia and membranoproliferative glomerulonephritis (MPGN), which is the most common glomerulonephritis. The aim of this study was to evaluate renal involvement in HCV-infected patients. MATERIALS AND METHODS: A total of 300 randomly-selected HCV antibody-positive outpatients at the HCV clinic of Shariati hospital were enrolled. Serum creatinine was measured and glomerular filtration rate was estimated accordingly. Urine proteinuria was measured in 24-hour urine samples. RESULTS: The patients were 249 men (83.2%) and 51 women (16.8%) with a mean age of 37.8 +/- 11.7 years (range, 18 to 70 years). Proteinuria was found in 12 HCV antibody-positive adults (4%), 1 of whom underwent biopsy. He was a 55- year-old man with a 4-month history of facial and lower extremities edema and 3-g proteinuria with a normal kidney function (glomerular filtration rate, 85 mL/min) and normocomplementemia. Kidney biopsy specimens showed MPGN. The frequency of low glomerular filtration rate was 0.7% (2 patients) in the HCV antibody-positive adults. There was no significant relationship between HCV seropositivity and low glomerular filtration rate. CONCLUSIONS: Our observations showed renal involvement in HCV antibody-positive patients. Among immune complex glomerular kidney diseases, MPGN without cryoglobulins is thought to be the most common in these patients. |
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Authors:
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Fereshteh Saddadi; Fatemeh Attari; Iraj Najafi; Mohammad Reza Gangi; Monirsadat Hakemi; Manochehr Amini |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Iranian journal of kidney diseases Volume: 4 ISSN: 1735-8582 ISO Abbreviation: Iran J Kidney Dis Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-11-30 Revised Date: 2011-05-17 |
Medline Journal Info:
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Nlm Unique ID: 101316967 Medline TA: Iran J Kidney Dis Country: Iran |
Other Details:
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Languages: eng Pagination: 123-7 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Medicine and Nephrology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. saddadi_md@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Creatinine / blood Cross-Sectional Studies Female Glomerular Filtration Rate Glomerulonephritis, Membranoproliferative / epidemiology, etiology*, virology Hepatitis C, Chronic / complications* Humans Immune Complex Diseases / etiology*, virology Iran / epidemiology Male Middle Aged Prevalence Proteinuria / epidemiology*, etiology Young Adult |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
| Comments/Corrections | |
Comment In:
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Iran J Kidney Dis. 2010 Oct;4(4):345
[PMID:
20852380
]
Iran J Kidney Dis. 2010 Jul;4(3):270-1 [PMID: 20622322 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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