Document Detail

Renal involvement in patients with hepatitis C virus infection.
MedLine Citation:
PMID:  20404422     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Hepatitis C virus (HCV) infection is a hepatotropic virus causing a variety of extrahepatic immunological manifestations and is a risk factor of a variety of extrahepatic diseases, such as mixed cryoglobulinemia and membranoproliferative glomerulonephritis (MPGN), which is the most common glomerulonephritis. The aim of this study was to evaluate renal involvement in HCV-infected patients.
MATERIALS AND METHODS: A total of 300 randomly-selected HCV antibody-positive outpatients at the HCV clinic of Shariati hospital were enrolled. Serum creatinine was measured and glomerular filtration rate was estimated accordingly. Urine proteinuria was measured in 24-hour urine samples.
RESULTS: The patients were 249 men (83.2%) and 51 women (16.8%) with a mean age of 37.8 +/- 11.7 years (range, 18 to 70 years). Proteinuria was found in 12 HCV antibody-positive adults (4%), 1 of whom underwent biopsy. He was a 55- year-old man with a 4-month history of facial and lower extremities edema and 3-g proteinuria with a normal kidney function (glomerular filtration rate, 85 mL/min) and normocomplementemia. Kidney biopsy specimens showed MPGN. The frequency of low glomerular filtration rate was 0.7% (2 patients) in the HCV antibody-positive adults. There was no significant relationship between HCV seropositivity and low glomerular filtration rate.
CONCLUSIONS: Our observations showed renal involvement in HCV antibody-positive patients. Among immune complex glomerular kidney diseases, MPGN without cryoglobulins is thought to be the most common in these patients.
Fereshteh Saddadi; Fatemeh Attari; Iraj Najafi; Mohammad Reza Gangi; Monirsadat Hakemi; Manochehr Amini
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Iranian journal of kidney diseases     Volume:  4     ISSN:  1735-8582     ISO Abbreviation:  Iran J Kidney Dis     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-11-30     Revised Date:  2011-05-17    
Medline Journal Info:
Nlm Unique ID:  101316967     Medline TA:  Iran J Kidney Dis     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
Division of Nephrology, Department of Medicine and Nephrology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Creatinine / blood
Cross-Sectional Studies
Glomerular Filtration Rate
Glomerulonephritis, Membranoproliferative / epidemiology,  etiology*,  virology
Hepatitis C, Chronic / complications*
Immune Complex Diseases / etiology*,  virology
Iran / epidemiology
Middle Aged
Proteinuria / epidemiology*,  etiology
Young Adult
Reg. No./Substance:
Comment In:
Iran J Kidney Dis. 2010 Oct;4(4):345   [PMID:  20852380 ]
Iran J Kidney Dis. 2010 Jul;4(3):270-1   [PMID:  20622322 ]

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