Document Detail

Renal insufficiency coexisting with heart failure is related to elevated sympathetic nerve activity.
MedLine Citation:
PMID:  20123156     Owner:  NLM     Status:  MEDLINE    
We investigated whether coexisting renal insufficiency (RI) is associated with elevated sympathetic activity in patients with heart failure (HF). Resting muscle sympathetic nerve activity (MSNA) was determined in 101 patients with HF (ejection fraction<0.45) and 8 patients with RI but without HF (RI group). Diagnosis of RI was made of glomerular filtration rates <60ml/min/1.73m(2) estimated using the simplified Modification of Diet in Renal Disease equation. Of 101 patients, 45 had RI (HFRI group) and 56 did not (HF group). HFRI group was older (p<0.05) and given loop diuretics more frequently (p<0.05), and had a lower specific activity scale (p<0.05) than HF group. HFRI group exhibited significantly greater MSNA indices than either HF group or RI group (burst rate, p<0.05; burst incidence, p<0.01). Univariate analysis showed that RI, age, specific activity scale level and dose of furosemide were significant predictors of increased burst incidence of MSNA in patients with HF. Notably, multivariate analysis revealed that RI was the only independent factor for increased MSNA indices. These findings suggest that coexisting RI is associated with elevated sympathetic activity in patients with HF.
Yoshitaka Oda; Shuji Joho; Daisuke Harada; Tadakazu Hirai; Hidetsugu Asanoi; Hiroshi Inoue
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Publication Detail:
Type:  Journal Article     Date:  2010-02-02
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  155     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  104-8     Citation Subset:  IM    
Second Department of Internal Medicine, University of Toyama, Toyama, Japan.
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MeSH Terms
Glomerular Filtration Rate
Heart Failure / complications*,  physiopathology*
Middle Aged
Muscle, Skeletal / innervation
Renal Insufficiency / complications*,  physiopathology
Sympathetic Nervous System / physiopathology*

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