Document Detail


Renal and hepatic aspects of ketoacidosis: a quantitative analysis based on energy turnover.
MedLine Citation:
PMID:  2656159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The central theme explored is that the rate of ATP production cannot exceed its rate of use in any organ or compartment. Thus the rate of ATP turnover exerts an absolute control over the rates in pathways that synthesize it. This is manifested in two major ways: substrate competition for oxidation and the influence of changes in oxygen consumption rate on the rate of fuel oxidation. By direct measurement, the rate of ketogenesis in the liver is as high as 1500 mmol/day during chronic ketoacidosis of fasting. Given the limited ate of hepatic oxygen consumption, ketogenesis and glucose synthesis from amino acids compete as precursors for hepatic ATP synthesis. Thus There is little room to increase the rate of ketoacid production further in these subjects. Energy turnover considerations in the kidney during chronic fasting seem to limit renal NH4+ production. In this case, there is competition between glutamine and ketone bodies as ATP precursors. This aspect may be important in the regulation of lean body mass catabolism of fasting. There is a "trade-off" in maintaining high circulating ketone body concentrations during fasting. The benefit is primarily for the CNS, and the cost is small loss of lean body mass owing to the need for high rates of NH4+ excretion.
Authors:
M L Halperin; S Cheema-Dhadli
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diabetes/metabolism reviews     Volume:  5     ISSN:  0742-4221     ISO Abbreviation:  Diabetes Metab Rev     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-11     Completed Date:  1989-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8601109     Medline TA:  Diabetes Metab Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-36     Citation Subset:  IM    
Affiliation:
Renal Division, St. Michael's Hospital, University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Acidosis / metabolism*
Animals
Energy Metabolism*
Humans
Ketone Bodies / metabolism
Ketosis / metabolism*
Kidney / metabolism*
Liver / metabolism*
Models, Biological
Chemical
Reg. No./Substance:
0/Ketone Bodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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