| Renal hemodynamics and electrolyte excretions after reserpine and ethanol. | |
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MedLine Citation:
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PMID: 1142094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The participation of the peripheral nervous system in the renal response to an acute ethanol administration was investigated in dogs. The animals received water or ethanol (3 g/kg), with and without 2 days pretreatment with reserpine. Each group was examined 18 hours after the water or ethanol administration. In comparison to water controls, both reserpine and ethanol produced similar increases with respect to renal hemodynamics. The combined treatment produced a further significant increase in effective renal plasma flow. Reserpine alone produced increases in the rates of filtration and reabsorption of sodium and chloride; ethanol and reserpine-ethanol treatments produced further increases but did not alter the excretory rates. Although all three treatments produced increases in the rate of filtration of potassium, only ethanol and reserpine-ethanol treatments increased the excretory rate. Magnesium excretion was decreased by reserpine and reserpine-ethanol in comparison to water and ethanol, respectively; but calcium excretion was elevated in all the treatment groups. Zinc excretion was increased in the ethanol group. The results suggest that the secondary action of ethanol to produce release and possible depletion of peripheral catecholamine stores is not primarily involved with its renal effects, except in the case of magnesium and zinc metabolism. |
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Authors:
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W Q Sargent; J R Simpson; J D Beard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 193 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1975 May |
Date Detail:
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Created Date: 1975-10-10 Completed Date: 1975-10-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 356-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / blood Chlorides / blood Dogs Ethanol / blood, pharmacology* Glomerular Filtration Rate / drug effects Hemodynamics / drug effects* Kidney / blood supply, metabolism, physiology* Magnesium / blood Male Potassium / blood Regional Blood Flow / drug effects Reserpine / pharmacology* Sodium / blood Water / pharmacology Zinc / blood |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 50-55-5/Reserpine; 64-17-5/Ethanol; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-66-6/Zinc; 7440-70-2/Calcium; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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