| Renal hemodynamic responses to dynamic exercise in rabbits. | |
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MedLine Citation:
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PMID: 9804559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular hemodynamics, including renal blood flow, were measured in rabbits with one intact and one denervated kidney during various intensities of treadmill exercise. Within the first 10 s of exercise, there was rapid vasoconstriction in the innervated kidney associated with decreases in renal blood flow (range -10 to -17%). The vasoconstriction in the innervated kidney was evident at all workloads and was intensity dependent. There was no significant vasoconstriction or change in renal blood flow (range 0.5 to -3.1%) in the denervated kidney at the onset of exercise. However, a slowly developing vasoconstriction occurred in the denervated kidney as exercise progressed to 2 min at all workloads. Examination of responses to exercise performed under alpha-adrenergic blockade with phentolamine (5 mg/kg iv) revealed that the vasoconstriction in the innervated kidney at the onset of exercise and the delayed vasoconstriction in the denervated kidney were due primarily to activation of alpha-adrenergic receptors. In addition, a residual vasoconstriction was also present in the innervated kidney after alpha-adrenergic blockade, suggesting that, during exercise, activation of other renal vasoconstrictor mechanisms occurs which is dependent on the presence of renal nerves. |
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Authors:
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P J Mueller; K P O'Hagan; K A Skogg; J B Buckwalter; P S Clifford |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 85 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-29 Completed Date: 1998-12-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1605-14 Citation Subset: IM |
Affiliation:
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Departments of Anesthesiology and Physiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Adrenergic alpha-Antagonists / pharmacology Animals Blood Pressure / physiology Denervation Female Formaldehyde / pharmacology Heart Rate / drug effects, physiology Kidney / innervation Norepinephrine / metabolism Phenylephrine / pharmacology Physical Exertion / physiology* Rabbits Receptors, Adrenergic, alpha / drug effects, physiology Reflex / physiology Renal Circulation / drug effects, physiology* Vasoconstriction / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha; 50-00-0/Formaldehyde; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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