Document Detail

Renal hemodynamic changes during serial seizures in rats.
MedLine Citation:
PMID:  1951738     Owner:  NLM     Status:  MEDLINE    
Renal blood flow (RBF) and mean arterial blood pressure (MABP) were measured during serially induced seizures in anesthetized paralyzed rats to investigate possible alterations in hemodynamic responses during experimental status epilepticus. During initial seizures, MABP increased from 143 to 193 mmHg, and RBF decreased from 4.8 to 1.5 ml/min. In contrast, MABP fell from 124 to 100 mmHg and RBF dropped from 3.6 to 2.8 ml/min during late seizures. The large decreases in RBF during initial seizures were blocked by renal denervation or bilateral adrenalectomy. During the period of late seizures, both the increase in MABP and the decrease in RBF in response to intravenous boluses of norepinephrine fell to 55% of the preseizure value. Our data indicate that the marked decreases in RBF during early seizures can be mediated by either the renal nerves or the adrenal glands. Furthermore, decreased sensitivity of the vasculature to norepinephrine likely contributes to the diminution of both MABP and RBF responses during later seizures.
R M Zweifler; E M Slaven; L L Rihn; J C Magee; N R Kreisman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  261     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-23     Completed Date:  1991-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1508-13     Citation Subset:  IM    
Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
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MeSH Terms
Blood Pressure*
Carbon Dioxide / blood
Kidney / innervation,  physiopathology*
Norepinephrine / pharmacology
Oxygen / blood
Partial Pressure
Rats, Inbred Strains
Reference Values
Renal Circulation / physiology*
Seizures / physiopathology*
Status Epilepticus / physiopathology
Reg. No./Substance:
124-38-9/Carbon Dioxide; 51-41-2/Norepinephrine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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