Document Detail

Renal hemodynamic changes after complete and partial unilateral ureteral obstruction in the fetal lamb.
MedLine Citation:
PMID:  9719277     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Complete and partial ureteral obstruction decreases ipsilateral renal blood flow in neonatal and adult animals. However, the effects of obstruction that develops during gestation may be different from those in neonatal or adult animals. We determine whether complete or partial ureteral obstruction decreases ipsilateral renal blood flow in fetal sheep. MATERIALS AND METHODS: We positioned an ultrasonic flow transducer around both renal arteries in 21 fetal sheep at 123 to 125 days of gestation. Unilateral ureteral obstruction was created in 16 fetuses, including complete and partial obstruction in 7 and 9, respectively. There were 5 controls. Renal blood flow and arterial blood pressure were measured daily for a minimum of 7 days. RESULTS: All obstructed kidneys had hydronephrosis, partially obstructed kidneys had less obstruction and contralateral kidneys had none. Renal weight was similar in obstructed and contralateral kidneys in the sham operated, partial and complete obstruction groups. After partial ureteral obstruction renal blood flow in obstructed and contralateral kidneys was increased compared to that in sham operated kidneys up to 11 days after obstruction was created. After complete ureteral obstruction the blood flow in obstructed kidneys was significantly lower than in the unobstructed counterparts but it remained 124% of initial renal blood flow at 10 days. Elevated ureteral pressure was maintained in obstructed kidneys throughout the study period. CONCLUSIONS: In our experiment partial ureteral obstruction in the fetus did not decrease renal blood flow to the ipsilateral kidney even after 7 days. Complete obstruction decreased blood flow in the affected kidney but not to same magnitude as that in previous adult animal studies. Our findings suggest that during gestation renal blood flow is maintained in the presence of obstruction.
H T Nguyen; B A Kogan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of urology     Volume:  160     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-09-17     Completed Date:  1998-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1063-9     Citation Subset:  AIM; IM    
Department of Urology, University of California School of Medicine, San Francisco 94143-0738, USA.
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MeSH Terms
Fetal Diseases / physiopathology*
Hydronephrosis / etiology
Renal Circulation / physiology*
Ureteral Obstruction / complications,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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