Document Detail

Renal haemodynamics prior to and after release of 24 hr unilateral ureteral ligation in the dog.
MedLine Citation:
PMID:  754489     Owner:  NLM     Status:  MEDLINE    
Renal functional parameters were investigated prior to and following release of 24 hr unilateral ureteral ligation (UUL). In the obstructd kidney renal blood flow (RBF) and glomerular filtration rate (GFR) decreased to about 50% and 14%, respectively, as compared to normal controls. Relief of the obstruction did not cause any change in renal haemodynamic parameters in the ligated kidney. Urine flow rate and urine osmolality in the previously obstructed kidney were decreased, the excreted fraction of filtered sodium increased as compared to the undisturbed kidney. The excretory lesion of the obstructed kidney is due to arteriolar, presumably preglomerular, vasoconstriction. Radioactive microspheres revealed that the decrease of RBF in the obstructed kidney was caused by diminished perfusion of the outer cortical zones, while blood flow to the inner cortical zones was unaltered. Fractional flow to the outer cortex was decreased, that to the inner cortex increased as compared with normal controls. In the undisturbed kidney there was a shifting of flow from the outer towards the inner cortex, while total blood flow remained unaltered.
K László; J Juszkó; P Bálint
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Academiae Scientiarum Hungaricae     Volume:  52     ISSN:  0001-6756     ISO Abbreviation:  Acta Physiol Acad Sci Hung     Publication Date:  1978  
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0371156     Medline TA:  Acta Physiol Acad Sci Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  71-86     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Glomerular Filtration Rate
Kidney / blood supply*
Kidney Function Tests
Regional Blood Flow
Ureteral Obstruction / etiology,  physiopathology*
Vascular Resistance

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