Document Detail


Renal glutamine metabolism in rats fed high-protein diets.
MedLine Citation:
PMID:  696820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of protein intake on acid excretion and renal glutamine metabolism was investigated and compared to the effects of NH4Cl-induced metabolic acidosis. Rats fed a diet containing 55% casein excreted more ammonia, phosphate, sulphate, and chloride than did rats fed a 13% casein diet, but, when they were given an 0.1 M NaHCO3 solution to drink, ammonia excretion was no longer elevated. Renal phosphate-dependent glutaminase and phosphoenolpyruvate carboxykinase activities, ammoniagenesis by isolated mitochondria, and the rate of renal gluconeogenesis were all elevated in the rats fed the high-protein diet but not if these rats also drank the sodium bicarbonate solution. Increased glutaminase and phosphoenolpyruvate carboxykinase activities, mitochondrial ammoniagenesis, and gluconeogenesis were all evident in rats made acidotic with NH4Cl. It is concluded that these metabolic adaptations evident in the kidneys of rats fed the high-protein diet are due to the acidogenic effects of increased protein intake.
Authors:
J T Brosnan; P McPhee; B Hall; D M Parry
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  235     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-11-29     Completed Date:  1978-11-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E261-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium
Ammonium Chloride / pharmacology
Animals
Dietary Proteins*
Glutaminase / metabolism
Glutamine / metabolism*
Kidney / enzymology,  metabolism*
Male
Mitochondria / metabolism
Phosphoenolpyruvate Carboxykinase (GTP) / metabolism
Rats
Chemical
Reg. No./Substance:
0/Dietary Proteins; 12125-02-9/Ammonium Chloride; 56-85-9/Glutamine; EC 3.5.1.2/Glutaminase; EC 4.1.1.32/Phosphoenolpyruvate Carboxykinase (GTP)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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