| Renal glucose transporters: novel targets for hyperglycemia management. | |
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MedLine Citation:
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PMID: 20351704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The naturally occurring substance phlorizin has long been recognized to block the reabsorption of glucose from the glomerular ultrafiltrate into the systemic circulation. The poor oral bioavailability and adverse effects associated with this agent, however, have prevented its use in clinical practice and restricted its use to that of a physiological tool. The development of novel agents that are able to block the principal glucose transporter in the kidney has allowed the inhibition of renal glucose reabsorption to be re-evaluated as a therapeutic tool in patients with diabetes mellitus. This Perspectives article summarizes current knowledge pertaining to glucose transport in the kidney and describes the evidence regarding glucose transport blockade as a novel target for the management of hyperglycemia in the context of existing treatment strategies. |
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Authors:
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Amanda Mather; Carol Pollock |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-30 |
Journal Detail:
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Title: Nature reviews. Nephrology Volume: 6 ISSN: 1759-507X ISO Abbreviation: Nat Rev Nephrol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500081 Medline TA: Nat Rev Nephrol Country: England |
Other Details:
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Languages: eng Pagination: 307-11 Citation Subset: IM |
Affiliation:
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Renal Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Availability Biological Transport Diabetic Nephropathies / physiopathology*, prevention & control* Glomerular Filtration Rate Glucose / metabolism* Humans Hyperglycemia / metabolism, physiopathology, prevention & control Hypoglycemic Agents / pharmacology Kidney / metabolism* Phlorhizin / pharmacology Sodium-Glucose Transporter 2 / antagonists & inhibitors*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/Sodium-Glucose Transporter 2; 50-99-7/Glucose; 60-81-1/Phlorhizin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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