| Renal function and systolic blood pressure in very-low-birth-weight infants 1-3 years of age. | |
| | |
MedLine Citation:
|
PMID: 22832668 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Preterm very-low-birth-weight (PT-VLBW) infants are at risk of an elevated systolic blood pressure (SBP) in infancy and adulthood; however, the pathogenesis remains unclear. Altered renal development or function may be associated with increased SBP, but their contribution in PT-VLBW is unknown. METHODS: We determined renal function and its relationship to SBP in three groups of PT-VLBW at 1, 2, and 3 years of age, using serum cystatin-C to calculate the estimated glomerular filtration rate (eGFR). RESULTS: Cystatin-C levels decreased from 0.84 ± 0.2 (SD) within the 1-year group to 0.70 ± 0.1 mg/l (±SD; P < 0.001) at 3 years and were unrelated to gender, fetal growth, and neonatal indomethacin exposure. eGFR rose from 121 ± 59 in the 1-year group to 138 ± 21 ml/min·1.73 m(2) (P < 0.001) at 3 years. At 1 year, cystatin-C levels decreased with increasing SBP (P < 0.007), and infants with SBP ≥ 90th% had lower cystatin-C and higher eGFR (P < 0.05). At 3 years, infants with lower birth weight (P < 0.03) and gestational age (P = 0.06) had reduced eGFR. CONCLUSIONS: Preterm very-low-birth-weight infants demonstrate increasing renal function with advancing age. An elevated SBP and eGFR at 1 year suggests dysfunctional renal autoregulation and hyperfiltration, which may alter subsequent renal function and contribute to the lower eGFR seen at 3 years in infants with the lowest birth weight and gestational age. |
| | |
Authors:
|
Joshua A Frankfurt; Andrea F Duncan; Roy J Heyne; Charles R Rosenfeld |
Related Documents
:
|
8464028 - Seasonal fluctuation in diurnal rhythms of luteinizing hormone secretion in ewes during... 7641568 - Seasonal incidence and ecology of the tick ixodes ricinus (acari: ixodidae) on grazing ... 21470268 - Analysis of binary outcomes from randomised trials including multiple births: when shou... 19719518 - Evolutionary ecology of human birth sex ratio under the compound influence of climate c... 9329438 - Serum free thyroxine concentration is not reduced in premature infants with respiratory... 3703518 - Epidemiology of neonatal conjunctivitis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-26 |
Journal Detail:
|
Title: Pediatric nephrology (Berlin, Germany) Volume: - ISSN: 1432-198X ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9002, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quality of life in children with end-stage renal disease based on a PedsQL ESRD module.
Next Document: Assessment of Near-Infrared Densitometry for in situ Determination of the Total Stratum Corneum Thic...