Document Detail


Renal function and sleep-disordered breathing in older men.
MedLine Citation:
PMID:  18644799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sleep-disordered breathing (SDB) is common in severe chronic kidney disease (CKD) and may contribute to morbidity and mortality in this population. However, the association between mild to moderate CKD and likelihood of SDB is uncertain.
METHODS: We studied 2696 men >or=65 years (mean 73.0 +/- 5.5) enrolled in the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) study who had serum creatinine (SCr) measured 3.4 years prior to overnight polysomnography (PSG). CKD was expressed as quartiles of estimated glomerular filtration rate (eGFR) using the four-variable Modification of Diet in Renal Disease (MDRD) formula. SDB was assessed using the respiratory disturbance index (RDI) with >or=4% oxygen desaturation.
RESULTS: Mean SCr was 0.99 +/- 0.20 mg/dl; 14.8% had eGFR <60 ml/min/1.73 m(2). Median RDI was 7.4 events/hour (inter-quartile range 2.6-15.8). Lower eGFR was not associated with higher mean RDI in the unadjusted model (P for trend = 0.180). There was evidence of an interaction between eGFR and age for the prediction of RDI; an association between lower eGFR and higher RDI was evident only among men <or=72 (median) years. Among this age group, however, the association was not statistically significant after further adjustment for body mass index (BMI) (P for trend = 0.278).
CONCLUSIONS: In this cohort of older community-dwelling men, reduced renal function was not associated with greater evidence of SDB, except among younger old men. However, this association was largely explained by higher BMI at lower eGFR. Further prospective study in younger populations is needed to clarify our findings.
Authors:
Muna T Canales; Li-Yung Lui; Brent C Taylor; Areef Ishani; Reena Mehra; Katie L Stone; Susan Redline; Kristine E Ensrud;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-07-20
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  23     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-03-02     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  3908-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Body Mass Index
Cohort Studies
Creatinine / blood
Glomerular Filtration Rate
Humans
Kidney / physiopathology*
Male
Renal Insufficiency, Chronic / complications,  pathology,  physiopathology
Sleep Apnea Syndromes / complications,  pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
R01 HL070837/HL/NHLBI NIH HHS; R01 HL070837/HL/NHLBI NIH HHS; R01 HL070838/HL/NHLBI NIH HHS; R01 HL070838/HL/NHLBI NIH HHS; R01 HL070839/HL/NHLBI NIH HHS; R01 HL070839/HL/NHLBI NIH HHS; R01 HL070841/HL/NHLBI NIH HHS; R01 HL070841/HL/NHLBI NIH HHS; R01 HL070842/HL/NHLBI NIH HHS; R01 HL070842/HL/NHLBI NIH HHS; R01 HL070847/HL/NHLBI NIH HHS; R01 HL070847/HL/NHLBI NIH HHS; R01 HL070848/HL/NHLBI NIH HHS; R01 HL070848/HL/NHLBI NIH HHS; R01 HL071194/HL/NHLBI NIH HHS; R01 HL071194/HL/NHLBI NIH HHS; R01 HL071194-01A1/HL/NHLBI NIH HHS; R01 HL071194-02/HL/NHLBI NIH HHS; R01 HL071194-03/HL/NHLBI NIH HHS; R01 HL071194-04/HL/NHLBI NIH HHS; R01 HL071194-05/HL/NHLBI NIH HHS; R01 HL071194-06/HL/NHLBI NIH HHS; T32 DK007784/DK/NIDDK NIH HHS; U01 AG018197/AG/NIA NIH HHS; U01 AG027810/AG/NIA NIH HHS; U01 AG18197/AG/NIA NIH HHS; U01 AR045580/AR/NIAMS NIH HHS; U01 AR045583/AR/NIAMS NIH HHS; U01 AR045614/AR/NIAMS NIH HHS; U01 AR045632/AR/NIAMS NIH HHS; U01 AR045647/AR/NIAMS NIH HHS; U01 AR045654/AR/NIAMS NIH HHS; U01 AR45580/AR/NIAMS NIH HHS; U01 AR45583/AR/NIAMS NIH HHS; U01 AR45614/AR/NIAMS NIH HHS; U01 AR45632/AR/NIAMS NIH HHS; U01 AR45647/AR/NIAMS NIH HHS; U01 AR45654/AR/NIAMS NIH HHS; U01-AG027810/AG/NIA NIH HHS; UL1 RR024140/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
AYI8EX34EU/Creatinine
Comments/Corrections

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