Document Detail


Renal function and organic anion and cation transport during dehydration and/or food restriction in chickens.
MedLine Citation:
PMID:  8766911     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of dehydration in the presence or absence of continued food intake on renal function was evaluated in chickens. In addition, renal transport of organic anions and cations under these conditions was assessed in vitro by uptake of 14C-para-aminohippuric acid and 14C-tetraethylammonium bromide by renal slices. Water restriction with continued food intake resulted in increases in serum osmolality and serum concentrations of sodium, uric acid, calcium and total protein. If food was restricted in addition to water, only serum osmolality and sodium concentration were significantly increased after 48 hours. Dehydration with continued access to food resulted in marked decreases in extracellular fluid volume, glomerular filtration rate and effective renal plasma flow. If food was restricted during dehydration, the decrease in effective renal plasma flow was attenuated despite reductions in glomerular filtration rate and extracellular fluid comparable to that seen in dehydrated birds allowed free access to food. Transport of organic anions was significantly increased after 24 and 48 hours of water restriction, regardless of whether food was withheld. Enhanced transport of organic anions in the presence of decreased glomerular filtration rate and effective renal plasma flow during dehydration may promote precipitation of urates and nephrosis in chickens.
Authors:
M J Radin; D E Swayne; A Gigliotti; T Hoepf
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology     Volume:  166     ISSN:  0174-1578     ISO Abbreviation:  J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol.     Publication Date:  1996  
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  8413200     Medline TA:  J Comp Physiol B     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  138-43     Citation Subset:  IM    
Affiliation:
Department of Veterinary Biosciences, Ohio State University, Columbus 43210, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Chemical Analysis
Body Weight
Chickens / metabolism,  physiology*
Dehydration* / metabolism
Extracellular Space
Food Deprivation*
Glomerular Filtration Rate / physiology
Histocytochemistry
Inulin / pharmacokinetics
Ion Transport / physiology*
Kidney / metabolism,  physiology*
Kidney Function Tests
Renal Plasma Flow, Effective / physiology
Tetraethylammonium
Tetraethylammonium Compounds / metabolism
p-Aminohippuric Acid / pharmacokinetics
Chemical
Reg. No./Substance:
0/Tetraethylammonium Compounds; 61-78-9/p-Aminohippuric Acid; 66-40-0/Tetraethylammonium; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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