Document Detail

Renal function influences interleukin-8 background production by cultured human mesothelial cells.
MedLine Citation:
PMID:  8865864     Owner:  NLM     Status:  MEDLINE    
Previous studies have demonstrated that mesothelial cells (MC) are important in the local host defense system of the peritoneal cavity. Most studies on the function of MC are performed on MC derived from material of patients with normal renal function (NRF). The aim of the present study was to examine differences in interleukin (IL)-8 expression by MC from patients with NRF and from patients with end-stage renal disease (ESRD). Therefore, MC were isolated from the omentum and pleural exudate of patients with NRF, from spent effluent of stable peritoneal dialysis (PD) patients, and from omentum obtained during catheter implantation prior to PD treatment. MC were stimulated with increasing doses of IL-1 beta or tumor necrosis factor-alpha for 24 hours, after which the supernatant was analyzed for IL-8 content. The IL-8 background level of MC isolated from patients with NRF was significantly lower than the IL-8 background level of MC derived from patients with ESRD. Although IL-8 production appeared to be higher in the ESRD MC, this difference was not significant after stimulation. While the overall immunity is depressed in uremia, MC are activated. The relatively high background of IL-8 might lead to an insensitivity of neutrophils by blocking the receptors and explain their impaired chemotaxis in uremia.
C E Visser; J J Brouwer-Steenbergen; P E Postmus; S Meijer; D G Struijk; R T Krediet; R H Beelen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  12     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  15-8     Citation Subset:  IM    
Department of Cell Biology and Immunology, Medical Faculty, Vrije Universiteit, Amsterdam, The Netherlands.
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MeSH Terms
Cells, Cultured
Epithelium / immunology
Immune Tolerance / immunology
Interleukin-8 / metabolism*
Kidney Failure, Chronic / immunology*,  therapy
Kidney Function Tests*
Middle Aged
Peritoneal Dialysis*
Peritoneum / immunology
Reference Values
Uremia / immunology,  therapy
Reg. No./Substance:

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