Document Detail


Renal function in normal and disordered pregnancy.
MedLine Citation:
PMID:  24247824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Renal dysfunction during pregnancy is a common and serious complication. Understanding normal physiology during pregnancy provides a context to further describe changes in pregnancy that lead to renal dysfunction and may provide clues to better management.
RECENT FINDINGS: Hormonal changes during pregnancy allow for increased blood flow to the kidneys and altered autoregulation such that glomerular filtration rate (GFR) increases significantly through reductions in net glomerular oncotic pressure and increased renal size. The mechanisms for maintenance of increased GFR change through the trimesters of pregnancy, continuing into the postpartum period. Important causes of pregnancy-specific renal dysfunction have been further studied, but much needs to be learned. Pre-eclampsia is due to abnormal placentation, with shifts in angiogenic proteins and the renin-angiotensin-aldosterone system leading to endothelial injury and clinical manifestations of hypertension and organ dysfunction. Other thrombotic microangiopathies occurring during pregnancy have been better defined as well, with new work focusing on the contribution of the complement system to these disorders.
SUMMARY: Advances have been made in understanding the physiology of the kidney in normal pregnancy. Diseases that affect the kidney during pregnancy alter this physiology in various ways that inform clinicians on pathogenesis and may lead to improved therapeutic approaches and better outcomes of pregnancy.
Authors:
Wael Hussein; Richard A Lafayette
Related Documents :
23445054 - System-level biomechanical approach for the evaluation of term and preterm pregnancy ma...
154114 - Midabdomen abdominoplasty.
8993174 - The relationship between apgar score and umbilical arterial blood gas values in newborns.
24247824 - Renal function in normal and disordered pregnancy.
18796334 - A cyanase is transcriptionally regulated by arginine and involved in cyanate decomposit...
3221094 - The development and evaluation of sevatest elisa hcg micro i. kit as a test for pregnancy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  23     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-12-05     Completed Date:  2014-07-28     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Female
Glomerular Filtration Rate
Hemodynamics
Humans
Kidney / physiopathology*
Models, Cardiovascular
Pre-Eclampsia / physiopathology
Pregnancy
Pregnancy Complications / physiopathology*
Thrombotic Microangiopathies / physiopathology
Grant Support
ID/Acronym/Agency:
T32 DK007357/DK/NIDDK NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the kidney.
Next Document:  Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii.