Document Detail

Renal function during therapy in patients with congestive cardiac failure. Ticrynafen vs. hydrochlorothiazide.
MedLine Citation:
PMID:  381954     Owner:  NLM     Status:  MEDLINE    
14 patients with congestive heart failure requiring diuretic therapy were randomly assigned to treatment with ticrynafen (TCRN) 250 mg or hydrochlorothiazide (HCTZ) 50 mg once or twice daily. Both diuretics were effective and comparable in effecting a significant weight loss and increase in urinary sodium. The major difference between the two compounds was the marked fall in serum uric acid concentration and the increase in uric acid clearance occurring with ticrynafen. HCTZ caused an increase in serum uric acid and a fall in uric acid clearance. It is concluded that ticrynafen is a useful diuretic in the treatment of congestive heart failure and has the advantage of lowering serum uric acid rather than producing hyperuricemia.
J W Smith; P Clements
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nephron     Volume:  23 Suppl 1     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1979  
Date Detail:
Created Date:  1979-10-24     Completed Date:  1979-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Diuretics / pharmacology,  therapeutic use*
Heart Failure / drug therapy*
Hydrochlorothiazide / pharmacology,  therapeutic use*
Middle Aged
Natriuresis / drug effects
Phenoxyacetates / pharmacology,  therapeutic use
Uric Acid / blood,  urine
Uricosuric Agents / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Diuretics; 0/Phenoxyacetates; 0/Uricosuric Agents; 58-93-5/Hydrochlorothiazide; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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