Document Detail

Renal function and blood pressure five years after puumala virus-induced nephropathy.
MedLine Citation:
PMID:  11012905     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome caused by Puumala hantavirus. Its long-term prognosis is considered favorable. Some reports suggest, however, that a previous hantavirus infection increases the risk of hypertension. METHODS: We studied 46 previously healthy subjects (26 males and 20 females, mean age of 44 years) who had serologically confirmed NE three to seven years previously, and 38 healthy, seronegative controls (22 males and 16 females, mean age of 44 years). Ambulatory blood pressure (ABP) was monitored. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were determined by 51CrEDTA and 131I-hippurate clearances, respectively. The filtration fraction (FF) was calculated. Quantitative 24-hour urinary protein excretion (UprotE) and timed overnight urinary excretion of alpha1-microglobulin were measured. RESULTS: The NE patients had a higher mean ambulatory systolic BP than the controls (123 +/- 13 vs. 117 +/- 9 mm Hg, P = 0. 008). GFR and FF were increased in patients compared with controls (GFR, 120 +/- 20 vs. 109 +/- 14 mL/min/1.73 m2, P = 0.006; FF, 19 +/- 3 vs. 18 +/- 3%, P = 0.030), but ERPF did not differ between the groups. The patients also had higher UPE than the controls (median 0. 18 g/day, range 0.12 to 0.38 vs. median 0.14 g/day, range 0.09 to 0. 24, P < 0.001, respectively). The overnight urinary excretion rate of alpha1-microglobulin exceeded 7 microg/min in nine patients. CONCLUSION: Three to seven years after NE, the patients had higher GFR and FF, more proteinuria, and higher ambulatory systolic BP compared with the healthy controls. NE may thus cause mild renal lesions and alterations in BP in some patients.
S Mäkelä; I Ala-Houhala; J Mustonen; A M Koivisto; T Kouri; V Turjanmaa; O Vapalahti; A Vaheri; A Pasternack
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  58     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-27     Completed Date:  2000-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1711-8     Citation Subset:  IM    
Medical School, University of Tampere, Tampere University Hospital, and Tampere School of Public Health, University of Tampere, Tampere, Finland.
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MeSH Terms
Blood Pressure*
Follow-Up Studies
Glomerular Filtration Rate
Hantavirus Infections / diagnosis,  physiopathology*
Kidney Failure, Acute / diagnosis,  physiopathology,  virology*
Membrane Glycoproteins / urine
Middle Aged
Nephritis / diagnosis,  physiopathology,  virology
Proteinuria / diagnosis,  physiopathology,  virology
Recovery of Function / physiology
Renal Circulation
Trypsin Inhibitor, Kunitz Soybean*
Reg. No./Substance:
0/Membrane Glycoproteins; 0/SPINT2 protein, human; 9088-41-9/Trypsin Inhibitor, Kunitz Soybean

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