Document Detail

Renal excretion of uric acid during prolonged fasting.
MedLine Citation:
PMID:  1263845     Owner:  NLM     Status:  MEDLINE    
Serum and urine uric acid were evaluated during prolonged therapeutic fasting in 15 obese patients. With increasing ketonemia the serum uric acid rose from a control value of 5.9 +/- 0.4 to 12.5 +/- 1.0 mg/100 ml at 7 days and then decreased progressively to 7.7 +/- 1.3 mg/100 ml by 28 days despite sustained ketonemia. The uric acid clearance were 5.5 +/- 0.9, 1.8 +/- 0.2, and 4.4 +/- 1.5 ml/min at days 0, 7, and 25 of fasting. At the same times the creatinine clearances were 114 +/- 11, 80 +/- 6, and 64 +/- 6.3 ml/min. There was no evidence of a renal tubular abnormality as assessed by glycosuria, bicarbonaturia, or increased phosphaturia. Urate binding to plasma proteins remained unchanged. Acute studies of the renal handling of uric acid revealed a uricosuric response to the administration of sodium lactate or sodium bicarbonate by intravenous infusion and low-dose acetylsalicylic acid orally. This renal tubular response departs significantly from that observed during the overnight fasted state and could not be accounted for by extracellular fluid volume expansion or the induced acid-base changes.
I H Fox; M L Halperin; M B Goldstein; E R Marliss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  25     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  551-9     Citation Subset:  IM    
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MeSH Terms
Aspirin / pharmacology
Bicarbonates / pharmacology
Hydroxybutyrates / metabolism
Kidney / metabolism*
Lactates / pharmacology
Metabolic Clearance Rate
Middle Aged
Obesity / diet therapy,  metabolism
Uric Acid / metabolism*
Reg. No./Substance:
0/Bicarbonates; 0/Hydroxybutyrates; 0/Lactates; 50-78-2/Aspirin; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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