| Renal effects of low-dose dopamine in patients with sepsis syndrome or septic shock treated with catecholamines. | |
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MedLine Citation:
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PMID: 8727434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the renal effects of low-dose dopamine in patients with sepsis syndrome or septic shock treated with catecholamines. DESIGN: Prospective, clinical study using sequential periods. SETTING: A 12-bed surgical intensive care unit in a university hospital. PATIENTS: 14 patients with sepsis syndrome and 15 patients with septic shock treated with exogenous catecholamines were studied. They had no diuretic treatment. INTERVENTION: Two periods of 2 h each with and without 2 micrograms.kg-1.min-1 of dopamine infusion. Hemodynamic and renal data were obtained at the end of each period. Measurements were repeated after 48 h of dopamine infusion in patients with sepsis syndrome. All data were evaluated by the Wilcoxon rank test. MEASUREMENTS AND RESULTS: In patients with sepsis syndrome, diuresis and creatinine clearance increased significantly by 100% and 60%, respectively, during low-dose dopamine infusion without any change in systemic hemodynamics. The renal response to dopamine decreased significantly after 48 h of dopamine infusion (P < 0.01). In patients with septic shock treated with catecholamines, no variation of either systemic hemodynamics or renal function was noted during low-dose dopamine infusion. CONCLUSION: The renal effects of low-dose dopamine in patients with sepsis syndrome decrease with time. No renal effect of low-dose dopamine was observed in patients with septic shock treated with catecholamines. These findings suggest a desensitization of renal dopaminergic receptors. |
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Authors:
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T Lherm; G Troché; M Rossignol; P Bordes; J F Zazzo |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Intensive care medicine Volume: 22 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-09-18 Completed Date: 1996-09-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 213-9 Citation Subset: IM |
Affiliation:
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Departement d'Anesthésie-Réanimation, Hôpital Antoine Béclère, Université Paris-Sud, Clamart, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Dopamine / administration & dosage, therapeutic use* Hemodynamics / drug effects Humans Infusions, Intravenous Kidney / drug effects* Middle Aged Prospective Studies Shock, Septic / drug therapy*, physiopathology Statistics, Nonparametric Survival Analysis Systemic Inflammatory Response Syndrome / drug therapy*, physiopathology Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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