Document Detail

Renal effects of hyperinsulinaemia in subjects with two hypertensive parents.
MedLine Citation:
PMID:  10585895     Owner:  NLM     Status:  MEDLINE    
The aim of this investigation was to study the effects of isoglycaemic hyperinsulinaemia on the renal metabolism of electrolytes and water in subjects with a strong genetic predisposition to essential hypertension, compared with that in non-predisposed subjects. We studied 25 normotensive subjects aged 18-35 years whose parents both had essential hypertension, and 22 age- and sex-matched subjects whose parents were both normotensive. Diabetes or morbid obesity in any subject or parent excluded the family. The 24-h blood pressure was measured. The subjects received an isocaloric diet with a fixed content of sodium and potassium for 4 days before the study. An isoglycaemic, hyperinsulinaemic clamp with infusion of insulin (40 munits.min(-1).m(-2)) was performed. We measured the renal clearance of diethylenetriaminepenta-acetic acid, sodium, potassium and lithium both under basal conditions and during hyperinsulinaemia. In response to hyperinsulinaemia, renal sodium clearance decreased to a significantly greater extent in the hypertension-prone subjects [0.57 (0.74, 0.36) ml.min(-1).1.73 m(2) (median and quartiles)] than in the controls [0.34 (0.56, 0.18) ml. min(-1).1.73 m(2)] (P=0.04). Compared with the controls, the subjects predisposed to hypertension had a higher 24-h diastolic blood pressure [78 (70, 82) mmHg, compared with 73 (68, 77) mmHg], but a similar insulin sensitivity index ¿10(7)x[313 (225, 427)] compared with 10(7)x[354 (218, 435)] l(2).min(-1).pmol(-1).kg(-1)¿. Thus the sodium-retaining effect of insulin was more pronounced in subjects with a strong genetic predisposition to essential hypertension than in subjects with normotensive parents. This effect may contribute to the development of hypertension in subjects with a genetic predisposition to hypertension.
U B Andersen; P Skøtt; N E Bruun; H Dige-Petersen; H Ibsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  97     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  681-7     Citation Subset:  IM    
Department of Clinical Physiology, Hvidovre Hospital, DK-2650 Hvidovre, Denmark.
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MeSH Terms
Case-Control Studies
Genetic Predisposition to Disease / genetics*
Hyperinsulinism / metabolism*
Hypertension / genetics*,  metabolism
Hypoglycemic Agents / diagnostic use
Insulin / diagnostic use
Kidney / metabolism*
Lithium / pharmacokinetics
Metabolic Clearance Rate
Pentetic Acid / pharmacokinetics
Potassium / pharmacokinetics
Sodium / pharmacokinetics*
Statistics, Nonparametric
Reg. No./Substance:
0/Hypoglycemic Agents; 11061-68-0/Insulin; 67-43-6/Pentetic Acid; 7439-93-2/Lithium; 7440-09-7/Potassium; 7440-23-5/Sodium

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