| Renal effects of concurrent E-24.11 and ACE inhibition in the aorto-venocaval fistula rat. | |
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MedLine Citation:
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PMID: 8922744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The present studies compare the early renal response to (a) an endopeptidase-24.11 (E-24.11) inhibitor (candoxatrilat) (b) an angiotensin-converting enzyme (ACE) inhibitor (lisinopril) and (c) the combination of endopeptidase-24.11 and ACE inhibition in the rat A-V fistula model of chronic volume overload. 2. Candoxatrilat (3 and 10 mg kg-1) i.v. produced a prompt 3 fold increase in urinary sodium and cyclic GMP excretion without affecting significantly blood pressure or glomerular filtration rate (GFR). 3. Lisinopril (0.03 mg kg-1) alone inhibited the pressor response to angiotensin I but had no significant effect on urinary sodium excretion or blood pressure. 4. Lisinopril (0.03 mg kg-1) attenuated significantly the early natriuretic response to candoxatrilat (3 mg kg-1) and the associated rise in urinary cyclic GMP, but sodium excretion eventually reached levels associated with acute E-24.11 inhibition. 5. Doses of the dual E-24.11/ACE inhibitor, sampatrilat, that inhibited the pressor response to angiotensin I reduced mean arterial blood pressure and produced a delayed natriuresis and rise in urinary cyclic GMP excretion when compared to candoxatrilat alone. 6. Concurrent administration of an ACE inhibitor reduces the early renal response to E-24.11 inhibition in the A-V fistula rat, an effect attributable to the hypotensive action of this combination. |
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Authors:
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J E Kirk; M R Wilkins |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 119 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-10 Completed Date: 1997-03-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 943-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Royal Postgraduate Medical School, London. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology* Animals Aorta* Arteriovenous Fistula / physiopathology* Kidney / drug effects*, physiopathology Lisinopril / pharmacology Male Natriuresis / drug effects* Neprilysin / pharmacology* Rats Rats, Wistar Venae Cavae* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 83915-83-7/Lisinopril; EC 3.4.24.11/Neprilysin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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