Document Detail

Renal effects of atrial natriuretic peptide in conscious rabbits with renal wrap hypertension.
MedLine Citation:
PMID:  2540927     Owner:  NLM     Status:  MEDLINE    
Atrial natriuretic peptide (ANP, 2 micrograms/min) was infused intravenously into rabbits four weeks after renal wrap or sham operation. Mean arterial pressure (MAP) averaged 132 +/- 4 mmHg in the renal wrapped rabbits and 89 +/- 3 mmHg in the sham rabbits, and glomerular filtration rate (GFR) was significantly lower in the hypertensive rabbits (6.2 +/- 1.0 ml/min) than in sham rabbits (8.9 +/- 0.7 ml/min). In sham rabbits, ANP caused a significant diuresis, natriuresis and increase in GFR. Enalapril pretreatment blunted these responses. In the hypertensive rabbits, ANP reduced mean arterial pressure but did not cause significant diuresis or natriuresis or change in GFR. Enalapril pretreatment did not significantly alter this response to ANP. In separate experiments, nitroprusside was infused to lower arterial pressure in hypertensive rabbits by a similar amount to that achieved with ANP and this reduced GFR, sodium and urine excretion rates. Thus ANP maintained GFR and sodium excretion in hypertensive rabbits compared to an equihypotensive dose of nitroprusside. In summary, ANP did not cause natriuresis or diuresis in renal wrapped kidneys at a dose which was effective in normal kidneys, but did maintain GFR, sodium and water excretion rates, compared to an equally hypotensive dose of nitroprusside.
M Takata; K M Denton; R L Woods; W P Anderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  11     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-20     Completed Date:  1989-06-20     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-74     Citation Subset:  IM    
Emily E.E. Stewart Renal Laboratory, Baker Medical Research Institute, Melbourne, Australia.
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MeSH Terms
Atrial Natriuretic Factor / blood,  pharmacology*
Enalapril / pharmacology
Glomerular Filtration Rate / drug effects
Hypertension, Renal / physiopathology*
Kidney / drug effects*,  physiopathology
Nitroprusside / pharmacology
Renin / blood
Reg. No./Substance:
15078-28-1/Nitroprusside; 75847-73-3/Enalapril; 85637-73-6/Atrial Natriuretic Factor; EC

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