Document Detail


Renal effect of meclofenamate in presence and absence of superfusion bioassay.
MedLine Citation:
PMID:  1266974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic blood pressure (SBP), renal blood flow (RBF), renal vascular resistance (RVR), and arterial and renal venous prostaglandin E (PGE) concentrations were determined in pentobarbital-anesthetized dogs.The effect of sodium meclofenamate infused into the renal artery was compared under two sets of conditions. In experiments carried out under control conditions, SBP, RBF, and RVR were stable and meclofenamate caused only a slight decrease in RBF (5.4%) and increase in RVR.
Authors:
S Satoh; B G Zimmerman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  230     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  711-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthranilic Acids / pharmacology*
Blood Pressure / drug effects
Dogs
Female
Kidney / blood supply*,  drug effects
Male
Meclofenamic Acid / pharmacology*
Perfusion
Prostaglandins E / blood*
Regional Blood Flow / drug effects
Renal Artery
Renal Veins
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Anthranilic Acids; 0/Prostaglandins E; 644-62-2/Meclofenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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