Document Detail

Renal dysfunction in patients with sickle cell anemia or sickle cell trait.
MedLine Citation:
PMID:  9876295     Owner:  NLM     Status:  MEDLINE    
Patients with sickle cell anemia (Hb SS) or sickle cell trait (Hb AS) may present several types of renal dysfunction; however, comparison of the prevalence of these abnormalities between these two groups and correlation with the duration of disease in a large number of patients have not been thoroughly investigated. In a cross-sectional study using immunoenzymometric assays to measure tubular proteinuria, microalbuminuria, measurement of creatinine clearance, urinary osmolality and analysis of urine sediment, we evaluated glomerular and tubular renal function in 106 adults and children with Hb SS (N = 66) or Hb AS (N = 40) with no renal failure (glomerular filtration rate (GFR) > 85 ml/min). The percentage of individuals with microalbuminuria was higher among Hb SS than among Hb AS patients (30 vs 8%, P < 0.0001). The prevalence of microhematuria was similar in both groups (26 vs 30%, respectively). Increased urinary levels of retinol-binding protein or beta 2-microglobulin were detected in only 3 Hb SS and 2 Hb AS patients. Urinary osmolality was reduced in patients with Hb SS or with Hb AS; however, it was particularly evident in Hb SS patients older than 15 years (median = 393 mOsm/kg, range = 366-469) compared with Hb AS patients (median = 541 mOsm/kg, range = 406-722). Thus, in addition to the frequently reported early reduction of urinary osmolality and increased GFR, nondysmorphic hematuria was found in 26 and 30% of patients with Hb SS or Hb AS, respectively. Microalbuminuria is an important marker of glomerular injury in patients with Hb SS and may also be demonstrated in some Hb AS individuals. Significant proximal tubular dysfunction is not a common feature in Hb SS and Hb AS population at this stage of the disease (i.e., GFR > 85 ml/min).
R Sesso; M A Almeida; M S Figueiredo; J O Bordin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  31     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  1257-62     Citation Subset:  IM    
Divisõe de Nefrologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brasil.
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MeSH Terms
Albuminuria / complications
Anemia, Sickle Cell / epidemiology,  physiopathology*
Child, Preschool
Cross-Sectional Studies
Fanconi Syndrome / complications,  epidemiology
Kidney / physiopathology*
Kidney Failure / complications
Kidney Glomerulus / physiopathology
Middle Aged
Sickle Cell Trait / epidemiology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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