Document Detail

Renal dysfunction in cadmium smelters: relation to in-vivo liver and kidney cadmium concentrations.
MedLine Citation:
PMID:  6133989     Owner:  NLM     Status:  MEDLINE    
Biochemical indicators of renal dysfunction have been compared with liver and kidney cadmium levels measured by neutron activation analysis in a group of 37 cadmium smelters. Higher than normal concentrations of cadmium in the liver reflect past exposure; they were associated with evidence of renal dysfunction in workers exposed to cadmium for more than 10 years. A small group of 6 workers exposed to cadmium for only a short time (mean = 4.6 years) had high hepatic cadmium concentrations but normal renal function. Longitudinal studies are required to establish the natural history of renal dysfunction following cadmium accumulation in industrial workers.
D Gompertz; D R Chettle; J G Fletcher; H Mason; J Perkins; M C Scott; N J Smith; M D Topping; M Blindt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1185-7     Citation Subset:  AIM; IM    
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MeSH Terms
Cadmium / analysis*
Cadmium Poisoning / complications
Kidney / analysis*
Kidney Diseases / etiology*
Liver / analysis*
Neutron Activation Analysis
Occupational Diseases*
Proteinuria / etiology
Time Factors
beta 2-Microglobulin / urine
Reg. No./Substance:
0/beta 2-Microglobulin; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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