Document Detail


Renal dysfunction of cadmium-exposed workers residing in a cadmium-polluted environment.
MedLine Citation:
PMID:  15688855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human exposure to cadmium may occur in both occupational and general environments. We were interested in determining whether a combination of occupational and environmental exposure to cadmium results in different levels of severity of renal dysfunction relative to that arising from environmental or occupational exposure alone. We selected 44 residents, who once were employed in a smelter and lived in a cadmium-polluted area, as group A. Another 88 subjects, who never worked in the plant, but lived in the same area, were selected as group B. Group C consisted of 88 subjects who had no history of occupational exposure to cadmium and lived in a non-cadmium-polluted area. Statistical analysis demonstrated that there was no significant difference in age or gender among the three groups, nor were there significant differences in smoking habits. The prevalence of renal dysfunction as indicated by increased excretion of beta2-microglobulin (B2M), N-acetyl-beta-D-glucosaminidase (NAG) and albumin (ALB), was higher in group A than in group B. This finding suggests that exposure to cadmium both occupationally and environmentally results in a higher prevalence of renal dysfunction, relative to those who are exposed to cadmium only in the general environment. Therefore, this specific population, who once were occupationally exposed to cadmium and lived in polluted areas, should be identified. Furthermore, health examinations of this population should be conducted in time to prevent further health damage induced by cadmium exposure.
Authors:
Taiyi Jin; Qinghu Kong; Tingting Ye; Xunwei Wu; Gunnar F Nordberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine     Volume:  17     ISSN:  0966-0844     ISO Abbreviation:  Biometals     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2005-02-03     Completed Date:  2005-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9208478     Medline TA:  Biometals     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  IM    
Affiliation:
Department of Occupational Health, School of Public Health, Fudan University 200032 Shanghai, PR China.
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosaminidase / urine
Adult
Albuminuria / chemically induced,  epidemiology
Cadmium / blood,  toxicity*,  urine
Cadmium Poisoning / complications*
China
Environmental Exposure*
Female
Humans
Kidney Failure / chemically induced*,  urine
Male
Middle Aged
Occupational Diseases
Occupational Exposure*
Prevalence
Smoking / adverse effects
beta 2-Microglobulin / urine
Chemical
Reg. No./Substance:
0/beta 2-Microglobulin; 7440-43-9/Cadmium; EC 3.2.1.52/Acetylglucosaminidase

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