Document Detail


Renal duplex parameters, blood pressure, and renal function in elderly people.
MedLine Citation:
PMID:  15861349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Changes in renal artery and renal parenchyma perfusion are believed to correlate with severity of hypertension and worsened renal function, but population-based studies of these associations are not available. This study examines relationships between parameters derived from renal duplex sonography (RDS), blood pressure (BP), and excretory renal function in a population-based cohort of elderly Americans. METHODS: Through an ancillary study to the Cardiovascular Health Study, 758 participants (37% men; mean age, 77 years) underwent RDS in which flow velocities and frequency shifts were determined from spectral analysis of Doppler-shifted signals obtained from the renal artery and parenchyma. Associations of these duplex parameters with BP and inverse serum creatinine were examined by using multivariate regression techniques. RESULTS: Main renal artery peak systolic flow velocity (PSV) showed independent associations with BP, with an SD increase in PSV (0.53 m/s) associated with a 3.3-mm Hg increase in systolic BP (SBP) and a 2.4-mm Hg decrease in diastolic BP (DBP). An SD decrease in end-diastolic frequency shift (EDF; 131 kHz) was associated with a 6.0-mm Hg increase in SBP, a 4.2-mm Hg decrease in DBP, and a significant 3.7% decrease in inverse serum creatinine. CONCLUSION: Increases in renal artery PSV and decreases in parenchymal EDF are associated with increased SBP and decreased DBP. Moreover, decreased parenchymal EDF showed significant associations with impaired excretory renal function. These results suggest that renal duplex parameters are associated with renal parenchymal changes caused by hypertension and progressive renal dysfunction in elderly people.
Authors:
Jeffrey D Pearce; Matthew S Edwards; Timothy E Craven; William P English; Matthew M Mondi; Scott W Reavis; Kimberley J Hansen
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  45     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-29     Completed Date:  2005-10-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  842-50     Citation Subset:  IM    
Affiliation:
Division of Surgical Sciences, Section on Vascular Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1095, USA.
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MeSH Terms
Descriptor/Qualifier:
African Americans / statistics & numerical data
Aged
Aging / physiology
Arteriosclerosis / complications,  diagnosis,  ultrasonography
Blood Pressure*
Cardiovascular Diseases / epidemiology
Cohort Studies
Creatinine / blood
Cross-Sectional Studies
Diastole
Disease Progression
European Continental Ancestry Group / statistics & numerical data
Female
Humans
Hypertension, Renovascular / epidemiology,  etiology
Kidney / physiopathology*,  ultrasonography*
Kidney Diseases / complications,  physiopathology,  ultrasonography
Kidney Function Tests
Male
Renal Artery / physiopathology,  ultrasonography*
Renal Artery Obstruction / complications,  diagnosis,  ultrasonography
Renal Circulation
Risk Factors
Sampling Studies
Systole
Ultrasonography, Doppler, Duplex*
United States / epidemiology
Grant Support
ID/Acronym/Agency:
1R01DK47414/DK/NIDDK NIH HHS; N01 HC-15103/HC/NHLBI NIH HHS; N01-HC-35129/HC/NHLBI NIH HHS; N01-HC-85079/HC/NHLBI NIH HHS; N01-HC-85080/HC/NHLBI NIH HHS; N01-HC-85081/HC/NHLBI NIH HHS; N01-HC-85082/HC/NHLBI NIH HHS; N01-HC-85083/HC/NHLBI NIH HHS; N01-HC-85084/HC/NHLBI NIH HHS; N01-HC-85085/HC/NHLBI NIH HHS; N01-HC-85086/HC/NHLBI NIH HHS
Chemical
Reg. No./Substance:
60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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