Document Detail


Renal denervation using catheter-based radiofrequency ablation with temperature control: renovascular safety profile and underlying mechanisms in a hypertensive canine model.
MedLine Citation:
PMID:  25051229     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Renal denervation is a novel method for hypertension treatment. In this study, we aimed to investigate the safety and efficacy of radiofrequency ablation (RFA) at ablation temperatures of 45 °C or 50 °C and its possible mechanisms. Methods: A hypertensive canine model was established by abdominal aortic constriction in 20 healthy hybrid dogs. These dogs were then randomly assigned to the treatment and the control groups, with dogs in the treatment group further randomly assigned to receive RFA at ablation temperatures of 45 °C or 50 °C. In the treatment group, RFA was performed at 1 month after modeling; renal angiography was performed at 2 months after ablation. The arterial vessels of the dogs were examined histologically with hematoxylin and eosin staining. Changes in blood pressure in the foreleg and whole-body norepinephrine spillover rate were also assessed. Results: No arterial stenosis, dissection, thrombosis or other abnormalities were detected in the treated vessels by renal angiography, yet histology results showed minimal to mild renal arterial injury. Renal denervation resulted in a marked decrease in the whole-body norepinephrine spillover rate (p < 0.05) in addition to significantly reducing blood pressure (p < 0.05), with no significant differences detected between the 45 °C and 50 °C subgroups for both (p > 0.05). Conclusion: Renal denervation can be performed without acute major adverse events, using catheter-based RFA with temperature control. The procedure was feasible in reducing blood pressure by at least partially inhibiting sympathetic drive and systemic sympathetic outflow.
Authors:
Huijie Li; Hang Yu; Chunyu Zeng; Yuqiang Fang; Duofen He; Xiaoqun Zhang; Chunlan Wen; Chengming Yang
Related Documents :
3777199 - Hemodynamic changes during onset of high-sodium one-kidney figure-8 renal hypertension.
7006849 - The effect of hemorrhagic hypotension on urinary kallikrein excretion, renin activity, ...
1907329 - The effects of extracorporeal shock wave lithotripsy on renal growth, function and arte...
2375549 - The effect of renal range dopamine and norepinephrine infusions on the renal vasculature.
24631229 - Evaluation of fluid bolus administration rates using ruggedized field intravenous systems.
1147009 - Right atrium and renal sodium excretion.
2721119 - Pitfalls in the assessment of cardiovascular reflexes in patients with sympathetic fail...
24986729 - Treatment of decompression illness with heliox: the best of both worlds?
23603609 - Neutron diffraction study of the non-fermi liquid compound ceniga2: magnetic behaviour ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-22
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  -     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A DFT study on the interaction between glycine molecules/radicals and the (8, 0) SiCNT.
Next Document:  Red wine extract decreases pro-inflammatory markers, nuclear factor-?B and inducible NOS, in experim...