Document Detail

Renal denervation normalizes pressure and baroreceptor reflex in high renin hypertension in conscious rats.
MedLine Citation:
PMID:  1735574     Owner:  NLM     Status:  MEDLINE    
High renin hypertension is usually accompanied by impairment of the baroreceptor reflexes. This feature has been mostly ascribed to overactivity of the renin-angiotensin system. However, renal nerves could also modulate the baroreceptor reflexes. In the present experiments, the effect of renal denervation on the depressed baroreceptor reflexes was studied in rats subjected to aortic ligation between the renal arteries. Renal denervation of the ischemic kidney was performed at the same time as aortic ligation. The resulting effects on arterial pressure, heart rate, plasma renin activity, and baroreceptor reflex control of heart rate were studied 10-12 days after ligation and denervation. Aortic ligation induced high levels of mean arterial pressure (166 +/- 6 versus 110 +/- 3 mm Hg in controls), heart rate (380 +/- 9 versus 352 +/- 8 beats per minute in controls), and plasma renin activity (44 +/- 5 versus 6 +/- 1.2 ng angiotensin I/ml/hr). The baroreceptor reflex sensitivity for bradycardia and tachycardia was significantly reduced (-0.18 +/- 0.04 and -0.18 +/- 0.05, respectively, versus -2.3 +/- 0.01 and -2.4 +2- 0.1 beats per minute per mm Hg in controls). Denervation of the ischemic kidney attenuated the development of hypertension in aortic-ligated rats (122 +/- 3 mm Hg), lowering heart rate (319 +/- 8 beats per minute) and normalizing baroreceptor reflex sensitivity to bradycardia (-2.0 +/- 0.2 beats per minute per mm Hg) and to tachycardia (-4.0 +/- 0.1 beats per minute per mm Hg). Plasma renin activity was also normalized (4.3 +/- 2.4 ng angiotensin I/ml/hr).(ABSTRACT TRUNCATED AT 250 WORDS)
V L Oliveira; M C Irigoyen; E D Moreira; C Strunz; E M Krieger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  19     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-06     Completed Date:  1992-03-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  II17-21     Citation Subset:  IM    
Heart Institute, University Hospital, Faculty of Medicine, University of São Paulo, Brazil.
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MeSH Terms
Blood Pressure / physiology*
Heart Rate / drug effects,  physiology
Hypertension / chemically induced,  physiopathology*
Kidney / innervation*
Pressoreceptors / physiology*
Rats, Inbred Strains
Renin / adverse effects,  blood
Reg. No./Substance:

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