Document Detail

Renal cyst epithelial transport in non-uremic polycystic kidney disease.
MedLine Citation:
PMID:  6341688     Owner:  NLM     Status:  MEDLINE    
Renal cyst epithelial transport of organic molecules was investigated during three separate cyst drainage procedures in a non-uremic patient with polycystic kidney disease (PCKD). Following constant intravenous insulin infusion, four of eight sampled cysts achieved concentrations exceeding those expected by glomerular filtration alone. Likewise, cyst concentrations of the filtered radionuclide Tc DTPA were up to 3.7 times simultaneous plasma levels. Both PAH and I-131 hippuran accumulated in all cysts suggesting intact tubular secretory mechanisms. Quantitative amino acid levels in two proximal nephron cysts were identical to serum. Since concentrations of inulin, DTPA, and amino acids exceed levels expected if cystic nephrons had normal glomerular filtration and tubular reabsorptive properties, other mechanisms are likely. Simple diffusion across altered epithelial surfaces could partially account for the observed cyst concentrations of each organic molecule and, by ion trapping, contribute to progressive cyst growth in PCKD.
C G Wickre; W M Bennett
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  23     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  514-8     Citation Subset:  IM    
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MeSH Terms
Biological Transport
Epithelium / metabolism
Glomerular Filtration Rate
Inulin / diagnostic use
Iodohippuric Acid / diagnostic use
Nephrons / metabolism
Pentetic Acid / diagnostic use
Polycystic Kidney Diseases / metabolism*
Technetium / diagnostic use
Technetium Tc 99m Pentetate
Water-Electrolyte Balance
p-Aminohippuric Acid / diagnostic use
Reg. No./Substance:
147-58-0/Iodohippuric Acid; 61-78-9/p-Aminohippuric Acid; 65454-61-7/Technetium Tc 99m Pentetate; 67-43-6/Pentetic Acid; 7440-26-8/Technetium; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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