Document Detail


Renal cortical levels of adenosine triphosphate: restoration after prolonged ischemia by in situ perfusion of ATP-MgCl2.
MedLine Citation:
PMID:  7008746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolic consequences of low-temperature kidney preservation by pulsatile perfusion and cold storage were evaluated in canine kidneys by serial adenosine triphosphate (ATP) determinations. Serial cortical ATP levels were determined (1) after optimal harvest, (2) after 60 minutes of warm ischemia, and (3) after 60 minutes of warm ischemia followed by an intra-aortic infusion of ATP-MgCl2. After 24 hours of preservation, cortical ATP levels were significantly greater when pulsatile perfusion was used-both after optimal harvest and after 60 minutes of warm ischemia. Cortical ATP levels were significantly greater at 24 hours in both perfused and cold-storage kidneys when an intra-aortic infusion of ATP-MgCl2 was used following ischemia. These results may explain the 24-hour limitation of cold storage as well as its inferior results following ischemia injury. Furthermore, since ATP is critical in cellular metabolism, the technique of intra-aortic ATP-MgCl2 infusion warrants further investigation in the field of organ preservation.
Authors:
P J Garvin; M Jellinek; R Morgan; J E Codd
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  116     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / administration & dosage,  metabolism*
Animals
Aorta
Chlorides / administration & dosage
Cold Temperature
Dogs
Ischemia
Kidney Cortex / blood supply,  metabolism*
Kidney Transplantation*
Magnesium / administration & dosage
Organ Preservation*
Perfusion
Time Factors
Tissue Preservation*
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Chlorides; 56-65-5/Adenosine Triphosphate; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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