Document Detail


Renal cortical interstitium and fluid absorption by peritubular capillaries.
MedLine Citation:
PMID:  8141318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Every minute, the cortical peritubular capillaries in a 1-g rat kidney take up more than 0.5 ml tubular reabsorbate. Studies of renal lymph and measurements of pressure in capillaries (Pc) and interstitium (Pi) indicate that normally the protein colloid osmotic pressure of peritubular capillary plasma (COPp) provides the necessary absorptive force, keeping Pi at 2-4 mmHg, i.e., 8-10 mmHg lower than Pc. At reduced COPp, continued delivery of fluid from the tubules automatically raises Pi to maintain capillary fluid uptake. The transient Pi response to sudden exposure of the kidney to subatmospheric pressure shows that such adjustment of forces may take place in only 5 s. Most remarkable, adjustment of forces may take place in only 5 s. Most remarkable, reabsorption continues during protein-free perfusion of the isolated rat kidney, apparently effected by a Pi exceeding Pc. A relative retardation of interstitial uptake of ferritin from plasma in this case suggests fluid reabsorption through both small and large pores in the capillary wall. Collapse of the capillaries is presumably prevented by tight tethering to the capillary wall, giving the narrow interstitium a very low compliance.
Authors:
K Aukland; R T Bogusky; E M Renkin
Related Documents :
4025558 - Importance of the liver during glucagon-mediated increases in canine renal hemodynamics.
6957678 - Nephron obstruction and tubuloglomerular feedback.
3192398 - A micropuncture assessment of the effects of contrast media of different osmolality.
6396438 - Nephron heterogeneity in ischemic acute renal failure.
2285648 - Portal hypertension: serotonin and pathogenesis.
6667628 - Comparison of the hypotensive effects of bendrofluazide, bumetanide and xipamide.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of physiology     Volume:  266     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-04-26     Completed Date:  1994-04-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F175-84     Citation Subset:  IM    
Affiliation:
Department of Human Physiology, University of California, Davis 95616.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Capillaries / anatomy & histology,  physiology*,  ultrastructure
Endothelium, Vascular / anatomy & histology,  physiology
Kidney Cortex / anatomy & histology,  blood supply,  physiology*
Models, Biological
Muscle, Smooth, Vascular / physiology
Rats
Grant Support
ID/Acronym/Agency:
HL-18010/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hereditary and acquired defects in signaling through the hormone-receptor-G protein complex.
Next Document:  Metabolic acidosis stimulates carbonic anhydrase activity in rabbit proximal tubule and medullary co...