Document Detail


Renal complications following heart transplantation in children: a single-center study.
MedLine Citation:
PMID:  12603215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Renal dysfunction is common following heajt transplantation (Tx) in adults, but little is known in children. Thus, a retrospective chajt review was performed in children who underwent heajt Tx at the Hospital for Sick Children between April 1994 and April 1999. The inclusion criteria were: age <18 years, survival >1 year post-Tx. The Schwajtz formula was used to calculate glomerular filtration rate (GFR). Decreased GFR was defined as <80 mL/min/1.73 m2. Changes in GFR were analyzed using Repeated Measures Analysis of Variance. Forty-one eligible children were included. The mean age at Tx was 7 years (range: 1 month to 16.7 years). The mean F/UP was 33 +/- 17 months, with 32/41 patients followed for at least 24 months. The GFR was decreased in 42% pre-Tx, and in 7.3% at the last F/UP (p = 0.0001). GFR did not decline significantly with time after Tx; in fact, GFR increased in the first year and remained stable afterwards (p = 0.0002). Acute renal dysfunction (ARD) episodes were common (12/41 children). Hypertension was diagnosed in 76% of children during the first year post-Tx, but persisted in only 11 (27%). GFR improves in the majority of children following heajt Tx. ARD episodes are frequent in the post-Tx period. Hypertension is common but does not persist.
Authors:
Véronique Phan; Lori J West; Derek Stephens; Diane Hébert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons     Volume:  3     ISSN:  1600-6135     ISO Abbreviation:  Am. J. Transplant.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-10-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100968638     Medline TA:  Am J Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  214-8     Citation Subset:  IM    
Affiliation:
Depajtment of Paediatrics, Paediatric Academic MultiOrgan Transplant Program, The Hospital for Sick Children (HSC), University of Toronto, Toronto, M5G 1X8, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Calcineurin / antagonists & inhibitors
Child
Child, Preschool
Comorbidity
Female
Follow-Up Studies
Glomerular Filtration Rate
Graft Rejection / epidemiology
Growth / physiology
Heart Transplantation / statistics & numerical data*
Humans
Hypertension / epidemiology
Incidence
Infant
Kidney Diseases / diagnosis,  epidemiology*,  physiopathology
Male
Ontario / epidemiology
Retrospective Studies
Risk Factors
Chemical
Reg. No./Substance:
EC 3.1.3.16/Calcineurin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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