Document Detail

Renal and circulatory dysfunction in cirrhosis: current management and future perspectives.
MedLine Citation:
PMID:  20850887     Owner:  NLM     Status:  MEDLINE    
Chronic liver diseases are amongst the top leading causes of death in Europe as well as in other areas of the world. Chronic liver diseases are characterized by unrelenting progression of liver inflammation and fibrosis over a prolonged period of time, usually more than 20 years, which may eventually lead to cirrhosis. Advanced cirrhosis leads to a complex syndrome of chronic liver failure which involves many different organs besides the liver, including the brain, heart and systemic circulation, adrenal glands, lungs, and kidneys. The high morbidity and mortality secondary to chronic liver failure is due to complications related to the dysfunction of these organs, either alone or, more frequently, in combination. Understanding the mechanisms leading to organ dysfunction is crucial to the development of strategies for treatment and prevention of complications of cirrhosis. This article reviews our current knowledge, as well as future perspectives, on the management of circulatory and renal dysfunction in chronic liver failure.
Elsa Solà; Pere Ginès
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-13
Journal Detail:
Title:  Journal of hepatology     Volume:  53     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2011-02-24     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1135-45     Citation Subset:  IM    
Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Catalunya, Spain.
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MeSH Terms
Ascites / physiopathology,  therapy
Cardiovascular System / physiopathology*
Edema / physiopathology,  therapy
Hepatorenal Syndrome / physiopathology,  therapy
Kidney / physiopathology*
Liver Cirrhosis / physiopathology*,  therapy*
Water-Electrolyte Imbalance / physiopathology,  therapy

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