Document Detail

Renal circulation and cellular metabolism during left ventricular assisted circulation: comparison study of pulsatile and nonpulsatile assists.
MedLine Citation:
PMID:  9212968     Owner:  NLM     Status:  MEDLINE    
We examined left ventricular assist during 6 h for an acute myocardial infarction model in pigs. The outflow cannula was placed in the ascending aorta and an inflow cannula in the left atrium. A pump (Pulsatile group: Zeon Medical and Nonpulsatile group: Nikkiso HPM-15) was connected to each cannula. Items measured were the regional blood flow of the cortex and the medulla in the kidney, renal arterial flow, arterial blood ketone body ratio (AKBR), lactate/pyruvic acid, BUN, creatinine and beta 2-microglobulin. After experimental study, the kidneys were removed, and a pathological study was performed. In the pulsatile assisted group, renal cortical blood flow increased but medulla blood flow decreased. On the other hand, in the nonpulsatile assisted group, both regional blood flows decreased. That means that in the pulsatile assisted group intrarenal redistribution improved, rather than in the nonpulsatile assisted group. The results of our study indicated that pulsatile assist produced superior circulation in the kidney, and the microcirculation on the cell level was superior as well in early treatment of acute left heart failure.
A Sezai; M Shiono; Y Orime; K Nakata; M Hata; H Yamada; M Iida; S Kashiwazaki; J Kinishita; M Nemoto; T Koujima; Y Sezai; T Saitoh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  21     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-24     Completed Date:  1997-09-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  830-5     Citation Subset:  IM    
Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Blood Pressure / physiology*
Blood Urea Nitrogen
Creatinine / urine
Disease Models, Animal
Erythrocytes / cytology,  pathology
Heart Failure / physiopathology,  therapy
Heart-Assist Devices / adverse effects,  standards*
Ketone Bodies / metabolism
Kidney / metabolism*,  physiopathology
Kidney Cortex / blood supply
Kidney Glomerulus / pathology
Kidney Medulla / blood supply
Kidney Tubules / pathology
Lactic Acid / urine
Microcirculation / physiology
Pulsatile Flow / physiology*
Pyruvic Acid / urine
Renal Circulation / physiology*
Shock, Cardiogenic / physiopathology,  therapy
Ventricular Function, Left / physiology
beta 2-Microglobulin / metabolism
Reg. No./Substance:
0/Ketone Bodies; 0/beta 2-Microglobulin; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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