Document Detail

Renal cellular response to ureteral obstruction: role of maturation and angiotensin II.
MedLine Citation:
PMID:  10409296     Owner:  NLM     Status:  MEDLINE    
Renal angiotensin II (ANG II) is increased as a result of unilateral ureteral obstruction (UUO), and angiotensin AT(2) receptors predominate over AT(1) receptors in the early postnatal period. To examine the renal cellular response to 3-day UUO in the neonatal and adult rat, AT(1) and AT(2) receptors were inhibited by losartan and PD-123319, respectively. Additional rats received exogenous ANG II, 0.5 mg. kg(-1). day(-1). Renal cellular proliferation and apoptosis were quantitated by proliferating cell nuclear antigen and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling technique, respectively. In the neonate, UUO reduced proliferation and increased tubular apoptosis. Losartan had no detectable cellular effect, whereas PD-123319 increased cellular proliferation and suppressed apoptosis, and exogenous ANG II stimulated apoptosis. In the adult, UUO increased cellular proliferation as well as apoptosis, whereas losartan, PD-123319, and exogenous ANG II did not alter the cellular response. In conclusion, UUO impairs renal growth in the neonate by reducing proliferation and stimulating apoptosis, at least in part through angiotensin AT(2) receptors. UUO stimulates both renal cellular proliferation and apoptosis in the adult, but these effects are independent of ANG II. We speculate that the unique early responses of the developing kidney to urinary tract obstruction are mediated by a highly activated renin-angiotensin system and preponderance of AT(2) receptors.
R L Chevalier; B A Thornhill; J T Wolstenholme
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-30     Completed Date:  1999-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F41-7     Citation Subset:  IM    
Department of Pediatrics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA.
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MeSH Terms
Age Factors
Angiotensin II / physiology*
Animals, Newborn
Imidazoles / pharmacology
Kidney / cytology*,  growth & development*
Losartan / pharmacology
Pyridines / pharmacology
Rats, Sprague-Dawley
Receptors, Angiotensin / antagonists & inhibitors
Ureteral Obstruction / physiopathology*
Grant Support
Reg. No./Substance:
0/Imidazoles; 0/Pyridines; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 130663-39-7/PD 123319

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