Document Detail

Renal calcifications: a complication of long-term furosemide therapy in preterm infants.
MedLine Citation:
PMID:  7110808     Owner:  NLM     Status:  MEDLINE    
During the last four years ten premature infants developed renal calcifications while receiving long-term furosemide therapy. The drug was used in infants with present ductus arteriosus and later in the same infants with chronic lung disease. They had received furosemide in a dose of at least 2 mg/kg/day for at least 12 days before calcifications were noted on abdominal roentgenograms. Calcifications included small flecks, isolated stones, staghorn calculi, and nephrocalcinosis. Analysis of stones received from our infants showed calcium oxalate and calcium phosphate. Infants who were not receiving furosemide had no calcifications. The infants with renal calcifications had rates of calcium excretion ten to 20 times that of normal, age-matched premature infants in our nursery. When chlorothiazide was given to the infants, in addition to furosemide, a four- to 15-fold decrease in calcium excretion and a radiologic dissolution of the renal calcifications were documented. It is concluded that furosemide, in doses of at least 2 mg/kg/day for at least 12 days can be associated with renal calcifications. The probable mechanism of the stone formation is hypercalciuria, primarily caused by furosemide.
K G Hufnagle; S N Khan; D Penn; A Cacciarelli; P Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  70     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  360-3     Citation Subset:  AIM; IM    
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MeSH Terms
Ductus Arteriosus, Patent / complications
Furosemide / adverse effects*,  therapeutic use
Heart Failure / drug therapy,  etiology
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Kidney Calculi / chemically induced*,  metabolism,  radiography
Respiratory Distress Syndrome, Newborn / drug therapy
Reg. No./Substance:

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